I-PREGABALIN (LYRICA) 300 MG X 56 CAPSULES

I-Pregabalin yathola imvume kwa-United States Food and Drug Administration (FDA) ngo-2004. Isetshenziselwa ukwelapha ubuhlungu nokuquleka. Thenga i-lyrica pregabalin 300mg ku-inthanethi e-Australia

Izinkomba ezigunyazwe yi-FDA[1][2][3][4]

• Ukwelashwa kobuhlungu be-neuropathic obuhambisana ne-diabetes peripheral neuropathy
• Ukwelashwa kobuhlungu be-neuropathic obuhambisana nokulimala komgogodla
• Ubuhlungu be-neuropathic obuvela ku-neuralgia ye-postherpetic
• Ukwelashwa kwe-fibromyalgia
• I-Adjunctive therapy yokuquleka okuyingxenye yabantu abadala abanesifo sokuwa. Thenga i-lyrica pregabalin 300mg ku-inthanethi e-Australia

Ukusetshenziswa okungeyona ilebula[5][6][7]

• Isifo sokukhathazeka ngokujwayelekile
• Ukuphazamiseka kokukhathazeka komphakathi
• Isifo se-bipolar
• Insomnia
• Izimo zobuhlungu obungapheli
• I-Pruritus engapheli
• Ukukhwehlela okungapheli
• I-Restless leg syndrome

Kukhona ukungavumelani okubalulekile mayelana nokusebenza kwe-pregabalin ezinkingeni zengqondo ezibalwe ngenhla. Ngakho-ke, odokotela kufanele baqaphele futhi baqaphe iziguli ukuze zithole impumelelo yokwelapha lapho belapha iziguli nge-pregabalin. Thenga i-lyrica pregabalin 300mg ku-inthanethi e-Australia

Indlela Yokusebenza

I-Pregabalin ngokwesakhiwo iyafana ne-inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Ishintshiwe yaba i-analogue ye-lipophilic ukuze kuthuthukiswe ukusakazeka kuwo wonke umgoqo wegazi nobuchopho. Kodwa-ke, i-pregabalin ayibophezeli ngokuqondile kuma-GABA-A noma ama-GABA-B receptors. Ukwengeza, ayenziwa i-metabolized ku-GABA receptor agonist. Kumamodeli ezilwane, i-pregabalin ibophezela eziteshini ze-calcium ze-presynaptic voltage-gated ku-alpha-2-delta subunit kumathishu wesistimu yezinzwa emaphakathi. Ukubophezela kwe-alpha-2-delta subunit kunciphisa ukungena kwe-calcium okubangelwa ukubola kwe-calcium kuma-neurons futhi kunciphisa ukukhululwa kwama-neurotransmitters ajabulisayo. Lesi senzo singase sibangele imiphumela ye-anticonvulsant ne-analgesic ye-pregabalin. I-Pregabalin ayinawo umsebenzi owaziwayo eziteshini ze-sodium, i-dopamine receptors, i-serotonin receptors, ama-opiate receptors futhi ayiguquli umsebenzi we-cyclooxygenase.[8] Thenga i-lyrica pregabalin 300mg ku-inthanethi e-Australia

Administration

I-Pregabalin ilawulwa ngomlomo futhi itholakala kuma-capsules noma izixazululo zomlomo. Ngemuva kokuphathwa ngomlomo, i-pregabalin ifinyelela ukugxila okuphezulu kwe-plasma kungakapheli amahora ayi-1.5 futhi ifinyelela isimo esiqinile phakathi namahora angama-24 kuye kwangama-48. Ukumuncwa kwe-pregabalin kuzimele kumthamo. U-Pregabalin weqa kalula umgoqo wegazi nobuchopho. Abantu abakwazi ukumetabolisa kakhulu i-pregabalin. Ukuqedwa kwayo ngokuyinhloko njengesidakamizwa esingashintshiwe (esingaphansi kuka-2% se-metabolized) ngokukhishwa kwezinso. Ezigulini ezinomsebenzi ojwayelekile wezinso, isilinganiso sempilo yesigamu sokuqedwa singamahora angama-6.3. Abacwaningi bafunde i-pregabalin ngemithamo efika ku-600 mg ngosuku. Kodwa-ke, abazange bathole i-600 mg ngosuku ukuze banikeze inzuzo eyengeziwe eyengeziwe futhi babekezeleleke kancane ngenxa yemiphumela emibi. Thenga i-lyrica pregabalin 300mg ku-inthanethi e-Australia

Izimo

• I-Pregabalin iphikisana neziguli ezine-hypersensitivity eyaziwayo ku-pregabalin. Ukusabela kwe-Hypersensitivity kwenzeka ezigulini ezithola i-pregabalin, kufaka phakathi i-angioedema.[19]
• Azikho izifundo ezanele nge-pregabalin kwabesifazane abakhulelwe. I-Pregabalin ingase ibangele ukulimala kwengane. Yazisa iziguli ukuthi kunengozi engaba khona ku-fetus.[20]
• I-Pregabalin itholwe obisini lwabesifazane abancelisayo; ngakho-ke, ukuncelisa ibele akukhuthazwa, futhi kukhethwa enye into.[15] Thenga i-lyrica pregabalin 300mg ku-inthanethi e-Australia