Indlela Yokusebenza

I-Oxycodone iyi-opioid ye-semisynthetic ene i-agonistic izakhiwo kuma-mu, i-kappa, kanye ne-delta-type opioid receptors, ukuhlobana okuqine kakhulu okwe-mu-type receptors. Lapho ibophezela kulawa ma-G-protein ahambisana nama-receptors, i-oxycodone ikhuthaza ukushintshaniswa kwe-GDP ku-G-alpha subunit ye-GTP, okuholela ekuvinjweni kwe-adenylate cyclase kanye nokuncipha kwe-intracellular cAMP. Lokhu kugeleza kwesignali kuholela ekuvinjweni okulandelanayo kwe-nociceptive neurotransmitters i-acetylcholine, i-dopamine, i-GABA, i-noradrenaline, ne-substance P kanye nama-hormone i-glucagon, i-insulin, i-somatostatin, ne-vasopressin. Thenga i-OxyNorm ku-inthanethi e-Australia - I-OxyNorm iyathengiswa e-Australia

Njengamanye ama-opioid, i-oxycodone kubangela i-hyperpolarization kanye nokuncipha kwe-excitability yama-neurons ohlelweni lwezinzwa oluphakathi (CNS). Lokhu kucindezeleka okujwayelekile kwe-CNS kubangelwa umphumela we-agonistic kuma-receptors ohlobo lwe-kappa, okuholela ekuvaleni iziteshi ze-calcium ezine-voltage-gated ye-N-type, kuyilapho ukukhuthazwa kwe-mu kanye nohlobo lwe-delta-receptor kuvula iziteshi ze-potassium ezithembele ku-calcium ngaphakathi. Thenga i-OxyNorm ku-inthanethi e-Australia - I-OxyNorm iyathengiswa e-Australia

I-Oxycodone igaywa ngama-enzyme e-hepatic CYP3A4 kanye ne-CYP2D6, akhiqiza i-metabolites noroxycodone ne-oxymorphone, ngokulandelana. Lawa ma-metabolites akhishwa emzimbeni ngezinso.

Administration

I-oxycodone itholakala kabanzi kuthebhulethi, i-capsule, nezixazululo zomlomo. Okwamanje itholakala ngamaphilisi angu-10-mg, 20-mg, 40-mg, noma 80-mg. Abakhiqizi bayeka umthamo we-160-mg ngoMeyi 2001 ngenxa yamandla aphezulu wokusebenzisa kabi. I-Oxycodone iyatholakala ngokuhlanganiswa namanye ama-analgesics, okuhlanganisa i-acetaminophen, i-aspirin, noma i-ibuprofen. Emazweni akhethiwe, i-oxycodone ingase itholakale nge-intramuscular kanye/noma amafomu emthanjeni futhi. Thenga i-OxyNorm ku-inthanethi e-Australia - I-OxyNorm iyathengiswa e-Australia

• Imithamo enconyiwe yokuqala ye-oxycodone iku-5 kuya ku-15 mg, njalo emahoreni ama-4 kuye kwayi-6 njengoba kudingeka ukuze uthole i-analgesia eyanele yobuhlungu obukhulu. Umthamo owengeziwe kufanele uhlehle ubheke phezulu njengoba kudingeka ekulawuleni ubuhlungu, ngokunaka nokuqapha imiphumela engemihle engaba khona.
• Iziguli ezine okungapheliyo ubuhlungu, kunconywa ukuthi unciphise umthamo ngendlela efanayo. Kodwa-ke, imithi kufanele ithathwe ngezikhathi ezihleliwe njalo ukuze kuvinjelwe ukuvela kabusha kobuhlungu ngokuphambene nokwelapha ubuhlungu ngemva kokuba buqalile. Thenga i-OxyNorm ku-inthanethi e-Australia - I-OxyNorm iyathengiswa e-Australia
• Amaphilisi enzelwe ukuthathwa ewonke futhi akufanele aphulwe, ahlafunwa, achotshozwe, noma ancibilikiswe oketshezini.
• Ukwehliswa komthamo kungadingeka kubantu asebekhulile kanye neziguli ezinokwehluleka kwesibindi noma kwezinso. Ukuqala umthamo wokuqala ngemithamo eyodwa kokuthathu ukuya kweyodwa kwemithamo evamile kanye nokuqapha okuseduze kuyanconywa. I-Titration phezulu kufanele iqhubeke ngezinga elicophelelayo.
• Ukuqala kwesenzo imizuzu eyi-10 kuye kwengama-30 yokwakhiwa kokukhishwa ngokushesha kanye nehora elingu-1 lokukhishwa okulawulwayo.
• Ibanga lobude besikhathi lisuka emahoreni angu-3 ukuya kwangu-6 ukuze likhishwe ngokushesha noma amahora angu-12 ekwakhiweni kokukhishwa okulawulwayo.
• Ukuphila kwesigamu se-plasma amahora ama-3 kuye kwayi-5, futhi amazinga azinzile e-plasma afinyelelwa emahoreni angama-24 kuye kwangama-36.