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THENGA I-OXYCODONE 30MG X 100 AMATHETHA KU-INTANETHI | I-MUSHROOMIFI

Name: I-OXYCODONE 30MG X 100 TABLETS - Thenga Amakhowe Omlingo Ku-inthanethi |MushroomiFi
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I-Oxycodone ibilokhu isetshenziswa emtholampilo kusukela ngo-1917. Thenga i-Oxycodone Oxycontin 30mg ku-inthanethi e-Australia
Inikezwe abantu ngomjovo (iv),
i-intramuscularly (im),
intranasally (ngaphakathi),
ngaphansi kwesikhumba (sc),
ngokweqiniso,
ngesifo sofuba,
futhi ngomlomo kusetshenziswa izixazululo ezikhishwa ngokushesha, kanye namaphilisi akhishwa ngokushesha noma okulawulwayo. Thenga i-Oxycodone Oxycontin 30mg ku-inthanethi e-Australia

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Umzila wokulawula we-transdermal uphinde wahlolwa ezilwaneni.

Namuhla i-oxycodone isetshenziswa kakhulu njengamaphilisi alawulwayo obuhlungu obungapheli. Isixazululo esikhishwa ngokushesha kanye namaphilisi asetshenziselwa ubuhlungu obukhulu noma ubuhlungu obudlulayo. I-oxycodone yomzali iyindlela enhle lapho ama-opioid engakwazi ukunikezwa ngomlomo. Thenga i-Oxycodone Oxycontin 30mg ku-inthanethi e-Australia.

Umlando | I-Oxycontin Yokulawula Ubuhlungu | I-Mushroomifi.

I-opium iqukethe amakilasi amabili amakhemikhali e-alkaloid, i-phenantrenes kanye ne-benzyl-isoquinolines. Enye ye-phenantrene alkaloids, i-thebaine, ekhona ku-0.2–0.8% we-opium etholakala I-Papaver somniferum futhi ku-90% walokho okukhishwe ku-morphine-free I-Papaver bracteatum, inobuthi ngokwedlulele futhi ayinazo izici zokuqeda ukuvuvukala. Nokho, iyisandulela esibalulekile semikhiqizo embalwa yoguquko, kuhlanganise ne-oxycodone.

I-Oxycodone yathathwa ku-thebaine ngo-1916 futhi yethulwa ekusebenzeni komtholampilo eJalimane ngo-1917.
Yayisetshenziswa enyakatho yeYurophu ikakhulukazi ezinhlungwini ezinzima. ECanada, e-Australia, nase-United States, yayisetshenziswa ngokuyinhloko njengenhlanganisela yesidakamizwa ne-acetaminophen, i-phenacetin, ne-caffeine ukuze kube nobuhlungu obulinganiselwe. E-Finland, i-oxycodone isetshenziswe njenge-opioid yomzali eyinhloko yobuhlungu obukhulu kusukela ngawo-1960. Thenga i-Oxycodone Oxycontin 30mg ku-inthanethi e-Australia.

IKhemistry kanye Nesayensi Yezokwelapha Eziyisisekelo | I-OxyContin 30 mg amaphilisi okukhululwa isikhathi eside | I-Mushroomifi.

I-molecule ye-oxycodone (6-deoxy-7,8-dehydro-14-hydroxy-3-O-methyl-6-oxomorphine) iqukethe ama-planar amabili (A no-B) namasongo amabili e-aliphatic (C no-D). Amaqembu abalulekile ezenzo ze-analgesic ze-phenantrenes axhunyaniswe nezikhundla C3, C6, kanye no-N.

I-Oxycodone ine-liposolubility efana ne-morphine, futhi yomibili i-lipid encane kakhulu encibilika kune-fentanyl.

- i-opioid receptor. Thenga i-Oxycodone Oxycontin 30mg ku-inthanethi e-Australia

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I-μ-opioid receptor ebophezelayo ukuhambisana kwe-oxycodone, nokho, ingaphansi kwaleyo ye-morphine noma i-methadone.

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I-Oxymorphone, i-metabolite esebenzayo ye-oxycodone, inobudlelwane obubophayo obuphezulu be-μ-opioid receptor.

I-oxymorphone ye-intramuscular ne-morphine yaqhathaniswa neziguli ezinobuhlungu obungapheli ngenxa yomdlavuza. I-oxymorphone ye-intramuscular ibonakale inamandla izikhathi ezingu-8.7 njenge-morphine ngokomphumela ophelele we-analgesic kanye nezikhathi ezingu-13 njengezinamandla ngokomphumela ophezulu.

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Ezifundweni zokuziphatha kumagundane, i-oxycodone iqhathaniswe ne morphine futhi ibonise i-antinociception ebuthaka kakhulu futhi emfushane ekuhlolweni kwe-flick nokushisa kwepuleti ngemva kokuphathwa kwe-intrathecal (it) kanye ne-intracerebroventricular (icv).
Ngemuva kokuphathwa kwe-systemic (i-subcutaneous noma i-intraperitoneal), i-oxycodone iboniswe ukuthi isebenza izikhathi ezingu-2-4 kune-morphine. Thenga i-Oxycodone Oxycontin 30mg ku-inthanethi e-Australia

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Le miphumela ibonise ukuthi ama-metabolites asebenzayo e-oxycodone (isb, i-oxymorphone) angabaluleka ku-oxycodone-mediated analgesia. Ucwaningo olusebenzisa amagundane e-Dark Aguti ashodayo ku-enzyme CYP2D1, edingekayo ku-O-demethylate oxycodone egundaneni, kanye nabaphikisi be-opioid receptor abahlukahlukene baphakamise ukuthi i-antinociceptive imiphumela ye-oxycodone ingaba yi-κ-opioid receptor-mediated.

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Ulwazi Olwengeziwe

Ubuningi

Ibhodlela eli-1, amabhodlela ama-2, amabhodlela ama-3, amabhodlela ama-4, amabhodlela ayi-5