I-PREGABALIN (LYRICA) 300 MG X 56 CAPSULES

I-Pregabalin ifumene imvume kwi-United States yoLawulo lokuTya kunye neDrug (FDA) kwi-2004. Isetyenziselwa ukunyanga iintlungu kunye nokuxhuzula. Thenga i-lyrica pregabalin 300mg kwi-intanethi e-Australia

Iimpawu ezivunywe yi-FDA[1][2][3][4]

• Unyango lweentlungu ze-neuropathic ezinxulumene ne-diabetes peripheral neuropathy
• Unyango lweentlungu ze-neuropathic ezinxulumene nokulimala komgogodla
• Iintlungu ze-neuropathic ezivela kwi-postherpetic neuralgia
• Unyango lwe-fibromyalgia
• Unyango olongezelelekileyo lokuxhuzula inxalenye yabantu abadala abanesifo sokuwa. Thenga i-lyrica pregabalin 300mg kwi-intanethi e-Australia

Usetyenziso olungasebenziyo[5][6][7]

• Ukuphazamiseka ngokubanzi koxinzelelo
• Ukuphazamiseka koxinzelelo lwentlalo
• Ukuxhuzula
• ugwayi
• Iimeko zeentlungu ezingapheliyo
• I-Pruritus engapheliyo
• Isikhohlela esinganyangekiyo
• I-Restless leg syndrome

Kukho ukungavumelani okubalulekileyo malunga nokusebenza kwe-pregabalin kwiziphazamiso zengqondo ezidweliswe ngasentla. Ke ngoko, ababhalisi kufuneka balumke kwaye babeke iliso kwizigulane zokuphumelela kwonyango xa benyanga izigulane nge-pregabalin. Thenga i-lyrica pregabalin 300mg kwi-intanethi e-Australia

Indlela yokuSebenza

I-Pregabalin yesakhiwo iyafana ne-inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Itshintshiwe ukuba ibe yi-analog ye-lipophilic ukomeleza ukusasazwa komqobo wegazi-ingqondo. Nangona kunjalo, i-pregabalin ayibopheleli ngokuthe ngqo kwi-GABA-A okanye i-GABA-B receptors. Ukongezelela, ayinayo i-metabolized kwi-GABA receptor agonist. Kwiimodeli zezilwanyana, i-pregabalin ibophelela kwi-presynaptic voltage-gated calcium channels kwi-alpha-2-delta subunit kwi-central nervous system tissues. Ukubophelela kwe-alpha-2-delta subunit kunciphisa i-depolarization-induced influx ye-calcium kwi-neurons kunye nokunciphisa ukukhululwa kwee-neurotransmitters ezinomdla. Esi senzo sinokubangela i-anticonvulsant kunye nemiphumo ye-analgesic ye-pregabalin. I-Pregabalin ayinayo umsebenzi owaziwayo kwiziteshi zesodium, i-dopamine receptors, i-serotonin zamkeli, i-opiate receptors kwaye ayiguquli umsebenzi we-cyclooxygenase.[8] Thenga i-lyrica pregabalin 300mg kwi-intanethi e-Australia

Administration

I-Pregabalin ilawulwa ngomlomo kwaye ifumaneka kwii-capsules okanye izisombululo zomlomo. Ukulandela ukulawulwa komlomo, i-pregabalin ifikelela kwi-peak concentrations ye-plasma phakathi kweeyure ze-1.5 kwaye ifezekisa imeko ezinzileyo ngaphakathi kwe-24 kwiiyure ze-48. Ukufunxwa kwe-pregabalin kuxhomekeke kwidosi. I-Pregabalin inqumla ngokukhawuleza umqobo wegazi-ubuchopho. Abantu abanakukwazi ukwenza i-pregabalin ngokubonakalayo. Ukupheliswa kwayo ngokuyinhloko njengechiza elingatshintshiyo (ngaphantsi kwe-2% ye-metabolized) nge-renal excretion. Kwizigulane ezinomsebenzi oqhelekileyo wezintso, ukupheliswa kwesiqingatha sobomi ziiyure ezingama-6.3. Abaphandi baye bafunda i-pregabalin kwiidosi ukuya kuthi ga kwi-600 mg ngosuku. Nangona kunjalo, abazange bafumane i-600 mg ngosuku ukubonelela ngenzuzo ebalulekileyo eyongezelelweyo kwaye yayinganyanzelwanga kakuhle ngenxa yemiphumo emibi. Thenga i-lyrica pregabalin 300mg kwi-intanethi e-Australia

Ukungqinelana

• I-Pregabalin ichasene nezigulane ezine-hypersensitivity eyaziwayo kwi-pregabalin. Ukusabela kwe-Hypersensitivity kuye kwenzeka kwizigulane ezifumana i-pregabalin, kuquka i-angioedema.[19]
• Akukho zifundo zaneleyo kunye ne-pregabalin kubasetyhini abakhulelweyo. I-Pregabalin inokubangela ingozi kumntwana. Cebisa izigulane kukho umngcipheko onokubakho kwi-fetus.[20]
• I-Pregabalin ifunyenwe kubisi lwabasetyhini abancancisayo; ngoko ke, ukuncancisa akucebisi, kwaye enye iarhente iyakhethwa.[15] Thenga i-lyrica pregabalin 300mg kwi-intanethi e-Australia