Indlela yokuSebenza

I-Oxycodone yi-opioid ye-semisynthetic ene i-agonistic iipropati kwi-mu, i-kappa, kunye ne-delta-uhlobo lwe-opioid receptors, kunye ne-affinity enamandla kakhulu ye-mu-type receptors. Emva kokubophelela kwezi receptor ze-G-protein ezidityanisiweyo, i-oxycodone ivuselela utshintshiselwano lwe-GDP kwi-G-alpha subunit ye-GTP, okukhokelela ekuvinjweni kwe-adenylate cyclase kunye nokuncipha kwe-intracellular cAMP. Lo mqondiso we-cascade ukhokelela ekuvinjweni kwe-nociceptive neurotransmitters i-acetylcholine, i-dopamine, i-GABA, i-noradrenaline, kunye ne-substance P kunye ne-hormone glucagon, i-insulin, i-somatostatin, kunye ne-vasopressin. Thenga i-OxyNorm kwi-intanethi eOstreliya-OxyNorm iyathengiswa eOstreliya

Njengezinye i-opioids, yioocodone kubangela i-hyperpolarization kunye nokunciphisa i-excitability ye-neurons kwinkqubo ye-nervous central (CNS). Olu nxunguphalo oluqhelekileyo lwe-CNS luphumela kwimpembelelo ye-agonistic kwi-kappa-type receptors, ekhokelela ekuvaleni i-N-type voltage-gated channels calcium, ngelixa ukukhuthazwa kwe-mu kunye ne-delta-type receptors kuvula i-calcium exhomekeke ngaphakathi-ukulungisa iziteshi ze-potassium. Thenga i-OxyNorm kwi-intanethi eOstreliya-OxyNorm iyathengiswa eOstreliya

I-Oxycodone i-metabolized yi-enzymes ye-hepatic CYP3A4 kunye ne-CYP2D6, ivelisa i-metabolites noroxycodone kunye ne-oxymorphone, ngokulandelanayo. Ezi metabolites zikhutshwa emzimbeni ngeentso.

Administration

IOxycodone ifumaneka ngokubanzi kwithebhulethi, i-capsule, kunye nezisombululo zomlomo. Okwangoku ifumaneka kwiipilisi ze-10-mg, i-20-mg, i-40-mg, okanye i-80-mg. Abavelisi bayeke i-dose ye-160-mg ngoMeyi 2001 ngenxa yokusetyenziswa kakubi okuphezulu. I-Oxycodone ifumaneka ngokudityaniswa nezinye ii-analgesics, kuquka i-acetaminophen, i-aspirin, okanye i-ibuprofen. Kumazwe athile, i-oxycodone inokufumaneka kwi-intramuscular kunye/okanye kwiifom ze-intravenous ngokunjalo. Thenga i-OxyNorm kwi-intanethi eOstreliya-OxyNorm iyathengiswa eOstreliya

• Iidosi ezicetyiswayo zokuqala ze-oxycodone zikuluhlu lwe-5 ukuya kwi-15 mg, zonke ii-4 kwiiyure ze-6 njengoko zifuneka kwi-analgesia eyaneleyo yeentlungu ezibuhlungu. Idosi eyongezelelekileyo kufuneka inyuke iye phezulu njengoko ifuneka kulawulo lweentlungu, ngokuqwalasela kunye nokubeka iliso kwiziphumo ebezingalindelekanga.
• Kwi zi gulane engapheliyo iintlungu, kucetyiswa ukuba ititrate ithamo ngendlela efanayo. Nangona kunjalo, iyeza kufuneka lithathwe ngamaxesha acwangcisiweyo rhoqo ukukhusela ukuphindaphinda kweentlungu ngokuchasene nokunyanga intlungu emva kokuba iqalile. Thenga i-OxyNorm kwi-intanethi eOstreliya-OxyNorm iyathengiswa eOstreliya
• Iipilisi zenzelwe ukuba zithathwe ziphelele kwaye akufuneki ziqhekezwe, zihlafunwa, zityunyuzwe, okanye zinyibilikiswe kulwelo.
• Ukunciphisa umthamo kunokuba yimfuneko kubantu abadala kunye nezigulane ezine-hepatic okanye izintso. Ukuqalisa idosi yokuqala kwisinye kwisithathu ukuya kwisiqingatha seedosi eziqhelekileyo kunye nokubekwa kweliso olusondeleyo kuyacetyiswa. I-Titration ukuya phezulu kufuneka iqhube ngesantya esilumkileyo.
• Ukuqala kwesenzo yi-10 kwimizuzu ye-30 yokuqulunqwa kwangoku ngokukhawuleza kunye neyure ye-1 yokukhutshwa okulawulwayo.
• Uluhlu lwexesha ukusuka kwi-3 ukuya kwiiyure ze-6 zokukhululwa ngokukhawuleza okanye iiyure ze-12 kwiifomyula ezilawulwayo.
• I-plasma-half-life yi-3 kwiiyure ze-5, kwaye amanqanaba e-plasma azinzileyo afikelela kwiiyure ezingama-24 ukuya kwii-36.