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THENGA I-OXYCODONE 30MG X 100 IITHEBLETHI KWI-INTANETHI | UMSHROOMIFI

Name: OXYCODONE 30MG X 100 TABLETS - Thenga Magic Mushroom Online |MushroomiFi
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I-Oxycodone ibisetyenziswa kwikliniki ukususela ngo-1917. Thenga i-Oxycodone Oxycontin 30mg kwi-intanethi e-Australia
Ifakwe ebantwini ngemithambo (iv),
nge-intramuscularly (im),
ngaphakathi (ngaphakathi),
ngaphantsi kwesikhumba (sc),
ngokuthe ngqo,
ngesifo,
kunye nomlomo usebenzisa izisombululo ezikhutshwa ngokukhawuleza, kunye neepilisi ezikhutshwe ngokukhawuleza kunye nokulawulwayo. Thenga i-Oxycodone Oxycontin 30mg kwi-intanethi e-Australia

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Indlela yokulawula i-transdermal nayo iye yavavanywa kwizilwanyana.

Namhlanje i-oxycodone isetyenziswa kakhulu njengeepilisi ezilawulwayo ezikhupha iintlungu ezingapheliyo. Isisombululo esikhawulezileyo kunye neepilisi zisetyenziselwa iintlungu ezibukhali okanye iintlungu eziphuma phambili. I-oxycodone yomzali yenye indlela efanelekileyo xa i-opioids ingenakukwazi ukusetyenziswa ngomlomo. Thenga i-Oxycodone Oxycontin 30mg kwi-intanethi e-Australia.

Imbali | I-Oxycontin yoLawulo lweentlungu | I-Mushroomifi.

I-opium iqulethe iiklasi ezimbini zeekhemikhali ze-alkaloids, i-phenantrenes kunye ne-benzyl-isoquinolines. Enye ye-phenantrene alkaloids, i-thebaine, ekhoyo kwi-0.2-0.8% ye-opium evela IPapaver somniferum kwaye kwi-90% yaloo nto ikhutshwe kwi-morphine-free I-Papaver bracteatum, inetyhefu kakhulu kwaye ayinazo iimpawu zokuthomalalisa iintlungu. Nangona kunjalo, i-precursor ebalulekileyo yeemveliso ezininzi zenguqu, kuquka i-oxycodone.

I-Oxycodone yafunyanwa kwi-thebaine ngo-1916 kwaye yaziswa kwikliniki yaseJamani ngo-1917.
Yayisetyenziswa emantla eYurophu ikakhulu kwiintlungu ezibukhali. EKhanada, eOstreliya, naseUnited States, yayisetyenziswa kakhulu njengechiza elidityanisiweyo ne-acetaminophen, i-phenacetin, kunye ne-caffeine kwiintlungu eziphakathi. EFinland, i-oxycodone isetyenziswe njengeyona ntsila iphambili ye-opioid yeentlungu ezibukhali ukusukela ngeminyaka yoo-1960. Thenga i-Oxycodone Oxycontin 30mg kwi-intanethi e-Australia.

IKhemistri kunye neSiseko sePharmacology | OxyContin 30 mg iipilisi zokukhulula ixesha elide | I-Mushroomifi.

I-oxycodone (i-6-deoxy-7,8-dehydro-14-hydroxy-3-O-methyl-6-oxomorphine) i-molecule iqukethe iiplani ezimbini (A kunye ne-B) kunye namakhonkco amabini e-aliphatic (C kunye no-D). Amaqela abalulekileyo kwizenzo ze-analgesic ze-phenantrenes zidibene nezikhundla ze-C3, i-C6, kunye ne-N.

I-Oxycodone ine-liposolubility efana ne-morphine, kwaye zombini zincinci kakhulu kwi-lipid enyibilikayo kune-fentanyl.

-i-opioid receptor. Thenga i-Oxycodone Oxycontin 30mg kwi-intanethi e-Australia

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I-μ-opioid receptor ebophelelayo ubudlelwane be-oxycodone, nangona kunjalo, ingaphantsi kwaleyo yemorphine okanye i-methadone.

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I-Oxymorphone, i-metabolite esebenzayo ye-oxycodone, inobudlelwane obubophezelayo obuphezulu be-μ-opioid receptor.

I-oxymorphone ye-intramuscular kunye ne-morphine yafaniswa kwizigulane ezineentlungu ezingapheliyo ngenxa yomhlaza. I-oxymorphone ye-Intramuscular ibonakalise ukuba ngamaxesha e-8.7 anamandla njenge-morphine ngokweempembelelo ze-analgesic epheleleyo kunye namaxesha e-13 anamandla ngokubhekiselele kwimpembelelo ephezulu.

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Kwizifundo zokuziphatha kwiimpuku, yioocodone ifaniswe ne icaffeine kwaye ibonise i-antinociception ebuthathaka kakhulu kunye ne-britterer kwi-flick yomsila kunye novavanyo lweplate eshushu emva kwe-intrathecal (it) kunye ne-intracerebroventricular (icv) yolawulo.
Emva kokulawulwa kwenkqubo (i-subcutaneous okanye i-intraperitoneal), i-oxycodone iboniswe ukuba ibe ngamaxesha angama-2-4 asebenzayo ngaphezu kwe-morphine. Thenga i-Oxycodone Oxycontin 30mg kwi-intanethi e-Australia

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Ezi ziphumo zibonise ukuba i-metabolites esebenzayo ye-oxycodone (umzekelo, i-oxymorphone) inokubaluleka kwi-oxycodone-mediated analgesia. Izifundo zisebenzisa iimpuku ze-Aguti eziMnyama ezinqongopheleyo kwi-enzyme ye-CYP2D1, efunekayo kwi-O-demethylate oxycodone kwi-rat, kunye neentlobo ezahlukeneyo ze-opioid receptor antagonists ziye zacebisa ukuba i-antinociceptive iziphumo ze-oxycodone zinokuba yi-κ-opioid receptor-mediated.

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