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Oxycodone has been in clinical use since 1917. Buy Oxycodone Oxycontin 30mg online in Australia
It has been administered to human beings intravenously (i.v.),
intramuscularly (i.m.),
intranasally (i.n.),
subcutaneously (s.c.),
rectally,
epidurally,
and orally using immediate-release solutions, and immediate- and controlled-release tablets. Buy Oxycodone Oxycontin 30mg online in Australia

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The transdermal route of administration has also been tested in animals.

Today oxycodone is mainly used as controlled-release tablets for chronic pain. The immediate- release solution and tablets are used for acute pain or for breakthrough pain. Parenteral oxycodone is a good alternative when opioids cannot be administered orally. Buy Oxycodone Oxycontin 30mg online in Australia.

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Opium contains two chemical classes of alkaloids, phenantrenes and benzyl-isoquinolines. One of the phenantrene alkaloids, thebaine, present in 0.2–0.8% of the opium derived from Papaver somniferum and in 90% of that extracted from morphine-free Gelincik bracteatum, is extremely toxic and lacks analgesic properties. It is, however, an important precursor of several transformation products, including oxycodone.

Oxycodone was derived from thebaine in 1916 and it was introduced into clinical practice in Germany in 1917.
It was used in northern Europe mainly for acute pain. In Canada, Australia, and the United States, it was used mainly as a combination drug with acetaminophen, phenacetin, and caffeine for moderate pain. In Finland, oxycodone has been used as the main parenteral opioid for acute pain since the 1960s. Buy Oxycodone Oxycontin 30mg online in Australia.

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The oxycodone (6-deoxy-7,8-dehydro-14-hydroxy-3-O-methyl-6-oxomorphine) molecule consists of two planar (A and B) and two aliphatic rings (C and D). Important groups for analgesic actions of the phenantrenes are linked to positions C3, C6, and N

Oxycodone has liposolubility similar to morphine, and both are significantly less lipid soluble than fentanyl.

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The μ-opioid receptor binding affinity of oxycodone is, however, less than that of morphine or methadone.

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Oxymorphone, the active metabolite of oxycodone, has a significantly higher μ-opioid receptor binding affinity.

Intramuscular oxymorphone and morphine were compared in patients with chronic pain due to cancer. Intramuscular oxymorphone proved to be 8.7 times as potent as morphine in terms of total analgesic effect and 13 times as potent in terms of peak effect.

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In behavioral studies in rats, oksikodon ile karşılaştırıldı morfin and has shown significantly weaker and briefer antinociception in the tail flick and hot plate tests after intrathecal (i.t.) and intracerebroventricular (i.c.v.) administration.
After systemic administration (subcutaneous or intraperitoneal), oxycodone was shown to be 2–4 times more effective than morphine. Buy Oxycodone Oxycontin 30mg online in Australia

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These results have indicated that the active metabolites of oxycodone (e.g., oxymorphone) could be important in oxycodone-mediated analgesia. Studies using Dark Aguti rats that are deficient in the enzyme CYP2D1, which is required to O-demethylate oxycodone in the rat, and various opioid receptor antagonists have suggested that the antinosiseptif effects of oxycodone could be κ-opioid receptor–mediated.

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