PREGABALIN (LYRICA) 300 MG X 56 CAPSULES

Pregabalin o ile a fumana tumello ho tsoa United States Food and Drug Administration (FDA) ka 2004. E sebelisoa ho phekola bohloko le ho oa. Reka lyrica pregabalin 300mg inthaneteng Australia

Lipontšo tse amohetsoeng ke FDA[1][2][3][4]

• Kalafo ea bohloko ba neuropathic bo amanang le lefu la tsoekere la peripheral neuropathy
• Kalafo ea bohloko ba neuropathic bo amanang le lesapo la mokokotlo
• Bohloko ba neuropathic bo tsoang ho postherpetic neuralgia
• Kalafo ea fibromyalgia
• Phekolo e thusang bakeng sa ho tsietsana ha karolo e itseng ho batho ba baholo ba nang le lefu la sethoathoa. Reka lyrica pregabalin 300mg inthaneteng Australia

Ts'ebeliso ea Off-label[5][6][7]

• Bofokoli bo akaretsang ba ho tšoenyeha
• Mathata a ho tšoenyeha ka sechaba
• Lefu la ho ferekana kelellong
• lefu la ho hlobaela
• Maemo a bohloko a sa foleng
• Pruritus e sa foleng
• Ho khohlela ho sa foleng
• Lefu la maoto le sa thekeseleng

Ho na le ho se lumellane ho hoholo mabapi le katleho ea pregabalin bakeng sa mafu a kelello a thathamisitsoeng ka holimo. Ka hona, lingaka li lokela ho ba hlokolosi le ho beha bakuli leihlo bakeng sa katleho ea kalafo ha ba phekola bakuli ba pregabalin. Reka lyrica pregabalin 300mg inthaneteng Australia

Mokhoa oa Khato

Pregabalin ka sebopeho se ts'oana le inhibitory neurotransmitter gamma-aminobutyric acid (GABA). E fetotsoe hore e be analoge ea lipophilic ho ntlafatsa phallo ho pholletsa le mokoallo oa mali le boko. Leha ho le joalo, pregabalin ha e tlamelle ka ho toba ho GABA-A kapa GABA-B receptors. Ho feta moo, ha e na metabolized ho GABA receptor agonist. Mehlala ea liphoofolo, pregabalin e hokahana le liteishene tsa calcium tsa presynaptic voltage-gated sebakeng sa alpha-2-delta subunit ea methapo ea methapo ea methapo. Ho tlamahane ha karoloana ea alpha-2-delta ho fokotsa phallo ea khalsiamo e bakoang ke depolarization ho li-neuron le ho fokotsa ho lokolloa ha li-neurotransmitters tse hlasimollang. Ketso ena e kanna ea ikarabella bakeng sa litlamorao tsa anticonvulsant le analgesic tsa pregabalin. Pregabalin ha e na ts'ebetso e tsejoang liteisheneng tsa sodium, li-receptor tsa dopamine, serotonin Li-receptors, li-opiate receptors 'me ha li fetole mosebetsi oa cyclooxygenase.[8] Reka lyrica pregabalin 300mg inthaneteng Australia

tsamaiso

Pregabalin e tsamaisoa ka molomo 'me e fumaneha ka li-capsules kapa litharollo tsa molomo. Kamora ho tsamaisoa ka molomo, pregabalin e fihla tlhorong ea plasma ea mali nakong ea lihora tse 1.5 mme e fihlella boemo bo tsitsitseng nakong ea lihora tse 24 ho isa ho tse 48. Ho kenngoa ha pregabalin ho itšetlehile ka tekanyo. Pregabalin e tšela habonolo mokoallo oa mali le boko. Batho ha ba khone ho sebelisa pregabalin haholo. Ho felisoa ha eona haholo-holo e le sethethefatsi se sa fetoheng (ka tlase ho 2% se entsoeng ka metabolized) ka ho tsoa ha renal. Ho bakuli ba nang le ts'ebetso e tloaelehileng ea renal, halofo ea bophelo ba ho felisoa ke lihora tse 6.3. Bafuputsi ba ithutile pregabalin ka litekanyetso tse fihlang ho 600 mg ka letsatsi. Leha ho le joalo, ha baa ka ba fumana 600 mg ka letsatsi ho fana ka molemo o eketsehileng oa bohlokoa 'me ba ne ba sa mamellehe hantle ka lebaka la litla-morao. Reka lyrica pregabalin 300mg inthaneteng Australia

Litlhōlisano

• Pregabalin e thibetsoe ho bakuli ba nang le hypersensitivity e tsebahalang ho pregabalin. Karabelo ea hypersensitivity e etsahetse ho bakuli ba fumanang pregabalin, ho kenyelletsa angioedema.[19]
• Ha ho na lithuto tse lekaneng ka pregabalin ho basali ba bakhachane. Pregabalin e ka baka kotsi ea lesea. Eletsa bakuli hore ho na le kotsi e ka hlahang ho lesea le ka pōpelong.[20]
• Pregabalin e fumanoe lebeseng la basali ba anyesang; ka hona, ho nyantša ha ho khothaletsoe, 'me ho khethoa moemeli e mong.[15] Reka lyrica pregabalin 300mg inthaneteng Australia