Mashruuca Hawlaha

Oxycodone waa opioid semisynthetic oo leh geesinimo guryaha mu, kappa, iyo nooca delta-opioid reseptors, oo leh xidhiidhka ugu xoogani waa mu-nooca reseptors. Marka lagu xidho kuwan G-protein-ku-soo-dhoweeyayaasha ah, oxycodone waxay kicisaa is-weydaarsiga GDP ee qaybta G-alfa ee GTP, taasoo keentay in la joojiyo adenylate cyclase iyo hoos u dhaca cAMP gudaha unugyada. Calaamaddan cascade waxay keenaysaa in la joojiyo natiijada nociceptive neurotransmitters acetylcholine, dopamine, GABA, noradrenaline, iyo walaxda P iyo hormoonnada glucagon, insulin, somatostatin, iyo vasopressin. Iibso OxyNorm online gudaha Australia – OxyNorm iibka Australia

Sida opioids kale, oxycodone sababa hyperpolarization iyo hoos u kicinta neurons ee habka dhexe ee neerfayaasha (CNS). Niyad-jabka CNS-ka guud wuxuu ka dhashaa saameynta agonistiga ah ee kappa-nooca receptors, taas oo horseedaysa xidhitaanka kanaalka kaalshiyamka-gated-gated N-nooca, halka kicinta mu iyo nooca delta-qabayaasha furmo kaalshiyam-ku-tiirsan gudaha-hagaajinta kanaalka potassium. Iibso OxyNorm online gudaha Australia – OxyNorm iibka Australia

Oxycodone waxaa metabolized by enzymes hepatic CYP3A4 iyo CYP2D6, soo saara metabolites noroxycodone iyo oxymorphone, siday u kala horreeyaan. Dheef-shiid kiimikaadkan ayaa jidhka ka soo baxa kelyaha.

Maamulka

Oxycodone ayaa si weyn loogu heli karaa kiniinka, kaabsal, iyo xalalka afka. Hadda waxa lagu heli karaa 10-mg, 20-mg, 40-mg, ama 80-mg pills. Wax-soo-saarayaashu waxay joojiyeen qiyaasta 160-mg bishii Maajo 2001 sababtoo ah awoodda sare ee si xun u isticmaalka. Oxycodone waxaa la heli karaa marka lagu daro daawooyinka kale ee xanuunka, oo ay ku jiraan acetaminophen, aspirin, ama ibuprofen. Wadamada la doortay, oxycodone waxa laga yaabaa in lagu heli karo foomamka muruqa iyo/ama xididada sidoo kale. Iibso OxyNorm online gudaha Australia – OxyNorm iibka Australia

• Qiyaasaha ugu horreeya ee lagu taliyey ee oxycodone waxay ku jiraan 5 ilaa 15 mg, 4 ilaa 6 saacadood kasta marka loo baahdo xanuunka xanuunka daran. Qaadashada dheeraadka ah waa in ay kor u kacdaa sida loogu baahan yahay xakameynta xanuunka, iyada oo fiiro gaar ah iyo la socoshada saameynaha suurtagalka ah.
• Bukaanka qaba raagay xanuunka, waxaa lagu talinayaa in titrate qiyaasta si la mid ah. Si kastaba ha ahaatee, daawada waa in la qaataa wakhtiyo jadwal ah oo joogto ah si looga hortago soo noqoshada xanuunka ee ka soo horjeeda daawaynta xanuunka ka dib marka uu bilaabo. Iibso OxyNorm online gudaha Australia – OxyNorm iibka Australia
• Kiniiniyada waxaa loogu talagalay in la wada qaato waana in aan la jebin, la calalin, la burburin, ama lagu milmin dareere.
• Dhimista qiyaasta ayaa laga yaabaa inay lagama maarmaan u tahay waayeelka iyo bukaanka qaba cagaarshow ama kelyaha. Bilawga qiyaasta bilawga ah saddex-meelood meel ilaa kala badh qiyaasaha caadiga ah iyo kormeer dhow ayaa lagula talinayaa. Kor u qaadista waa inay ku socotaa si taxadar leh.
• Bilawga ficilku waa 10 ilaa 30 daqiiqo diyaarinta-si daynta degdega ah iyo ilaa 1 saac ee siidaynta la xakameeyey.
• Muddadu waxay u dhaxaysaa 3 ilaa 6 saacadood si degdeg ah ama 12 saacadood oo qaabaynta la xakameeyey.
• Nolosha nuska ah ee balaasmaha waa 3 ilaa 5 saacadood, iyo heerarka balasmaha oo xasiloon ayaa lagu gaaraa 24 ilaa 36 saacadood gudahood.