PREGABALIN (LYRICA) 300 MG X 56 CAPSULES

Pregabalin akawana mvumo kubva kuUnited States Food and Drug Administration (FDA) muna 2004. Inoshandiswa kurapa marwadzo uye pfari. Tenga lyrica pregabalin 300mg online muAustralia

FDA-yakatenderwa Zviratidzo[1][2][3][4]

• Kurapa kwemarwadzo europathic ane chokuita nechirwere cheshuga peripheral neuropathy
• Kurapa kwekurwadziwa kweuropathic kunobatanidza nekukuvara kwemusana
• Neuropathic kurwadziwa kunobva kune postherpetic neuralgia
• Kurapa kwe fibromyalgia
• Adjunctive therapy ye partial-start sezures muvakuru vane pfari. Tenga lyrica pregabalin 300mg online muAustralia

Off-label Zvishandiso[5][6][7]

• General kusagadzikana kusagadzikana
• Kunetseka kwemagariro
• Bipolar disorder
• kutadza kurara
• Marwadzo asingaperi
• Chronic Pruritus
• Chisingaperi chikosoro
• Restless leg syndrome

Pane kusawirirana kukuru maererano nekubudirira kwe pregabalin yezvirwere zvepfungwa zvakanyorwa pamusoro apa. Naizvozvo, vanyori vanofanirwa kungwarira uye kutarisa varwere kuti vabudirire mukurapa pakurapa varwere vane pregabalin. Tenga lyrica pregabalin 300mg online muAustralia

Mechanism of Action

Pregabalin yakarongeka yakafanana neiyo inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Yakagadziridzwa kuita lipophilic analogi kuti iwedzere kupararira kweropa-brain barriers. Nekudaro, pregabalin haisungiri zvakananga kuGABA-A kana GABA-B receptors. Uyezve, haina kugadzirwa kune GABA receptor agonist. Mune mhando dzemhuka, pregabalin inosunga kune presynaptic voltage-gated calcium chiteshi pane alpha-2-delta subunit iri pakati penheyo system tishu. Iko kusungirirwa kwealpha-2-delta subunit kunoderedza depolarization-induced kupinda kwecalcium muneurons uye kunoderedza kusunungurwa kwemaurotransmitters anofadza. Ichi chiito chinogona kukonzera anticonvulsant uye analgesic mhedzisiro ye pregabalin. Pregabalin haina basa rinozivikanwa pa sodium chiteshi, dopamine receptors, serotonin Receptors, opiate receptors uye haigadzirise cyclooxygenase basa.[8] Tenga lyrica pregabalin 300mg online muAustralia

adhimini

Pregabalin inobatwa nemuromo uye inowanikwa mu capsules kana oral solutions. Kutevera kutungamirirwa nemuromo, pregabalin inosvika pakukwirira kweplasma mukati meawa 1.5 uye inowana kugadzikana-mamiriro mukati me24 kusvika kumaawa 48. Kutorwa kwe pregabalin kwakazvimiririra pane dose. Pregabalin inoyambuka zviri nyore chipingamupinyi cheropa-uropi. Vanhu havagone metabolize pregabalin zvakanyanya. Kubviswa kwayo kunonyanya kuve semushonga usina kuchinjwa (pasi pe2% metabolized) nekubuda kwerenal. Muvarwere vane zvakajairika renal basa, zvinoreva kubvisa hafu yeupenyu maawa 6.3. Vatsvagiri vakadzidza pregabalin pamadosi anosvika 600 mg pazuva. Zvisinei, havana kuwana 600 mg pazuva kuti vape rubatsiro rwakanyanya uye rwakanga rwakanyanya kushivirira nekuda kwemigumisiro. Tenga lyrica pregabalin 300mg online muAustralia

Contraindications

• Pregabalin inopesana nevarwere vane hypersensitivity kune pregabalin inozivikanwa. Hypersensitivity reaction yakaitika kune varwere vanogamuchira pregabalin, kusanganisira angioedema.[19]
• Iko hakuna zvidzidzo zvakakwana ne pregabalin muvakadzi vane pamuviri. Pregabalin inogona kukuvadza fetal. Rairira varwere kuti pane njodzi inogona kuitika kune fetus.[20]
• Pregabalin yakaonekwa mumukaka wevakadzi vanoyamwisa; saka, kuyamwisa hakukurudzirwe, uye imwe mumiriri inosarudzwa.[15] Tenga lyrica pregabalin 300mg online muAustralia