Mechanism of Action

Oxycodone inonzi semisynthetic opioid ine agonistic zvivakwa pamu, kappa, uye delta-mhando opioid receptors, ine hukama hwakasimba huri hwemu-mhando receptors. Pakusunga kune aya G-protein akabatanidzwa receptors, oxycodone inokurudzira kuchinjana kweGDP paG-alpha subunit yeGTP, zvichiita kuti inhibition yeadenylate cyclase uye kuderera kwe intracellular cAMP. Ichi chiratidzo chinoputika chinotungamirira kune inhibition inoguma ye nociceptive neurotransmitters acetylcholine, dopamine, GABA, noradrenaline, uye chinhu P uye mahomoni glucagon, insulini, somatostatin, uye vasopressin. Tenga OxyNorm pamhepo muAustralia - OxyNorm iri kutengeswa kuAustralia

Sezvimwe nemamwe maopioid, oxycodone inokonzeresa hyperpolarization uye kuderedza kunakidzwa kwemaneuroni mukati mepakati tsinga system (CNS). Izvi zvakazara CNS kuora mwoyo kunobva kune agonistic effect pa kappa-type receptors, iyo inotungamirira kuvharwa kweN-type voltage-gated calcium channels, apo kukurudzira kwemu uye delta-type receptors kunovhura calcium-inotsamira mukati-inogadzirisa nzira dze potassium. Tenga OxyNorm pamhepo muAustralia - OxyNorm iri kutengeswa kuAustralia

Oxycodone inogadziriswa nehepatic enzymes CYP3A4 uye CYP2D6, inogadzira metabolites noroxycodone uye oxymorphone, maererano. Aya metabolites anoburitswa kubva mumuviri kuburikidza neitsvo.

adhimini

Oxecodone inowanikwa zvakanyanya muhwendefa, capsule, uye mhinduro dzemuromo. Iko ikozvino inowanikwa mu10-mg, 20-mg, 40-mg, kana 80-mg mapiritsi. Vagadziri vakarega 160-mg dose muna May 2001 nekuda kwekunyanya kushandiswa zvisina kunaka. Oxycodone inowanikwa pamwe chete nemamwe analgesics, kusanganisira acetaminophen, aspirin, kana ibuprofen. Munyika dzakasarudzwa, oxycodone inogona kuwanikwa mune intramuscular uye/kana intravenous mafomu zvakare. Tenga OxyNorm pamhepo muAustralia - OxyNorm iri kutengeswa kuAustralia

• Madosi ekutanga anokurudzirwa eoxycodone ari mu5 kusvika ku15 mg range, yega yega 4 kusvika kumaawa 6 sezvinodiwa kuti awane analgesia yakakwana yekurwadziwa kwakanyanya. Kuwedzera dosing kunofanirwa kukwira kumusoro sezvinodiwa pakudzora marwadzo, nekutarisisa uye kutarisa kwezvingangoita mhedzisiro.
• Kune varwere vane tora nguva refu marwadzo, zvinokurudzirwa kuti titrate dosage nenzira imwecheteyo. Zvisinei, mishonga inofanira kutorwa panguva dzakarongwa nguva dzose kudzivirira kudzokazve kwemarwadzo kunze kwekurapa marwadzo mushure mokunge atanga. Tenga OxyNorm pamhepo muAustralia - OxyNorm iri kutengeswa kuAustralia
• Mapiritsi anoitirwa kutorwa ese uye haafanire kuputswa, kutsenga, kupwanywa, kana kunyungudika mumvura.
• Kuderedzwa kwedosi kunogona kuve kwakakosha kune vakwegura uye varwere vane hepatic kana renal kukundikana. Kutanga dhigirii rekutanga pachikamu chimwe chete muzvitatu kusvika kuhafu yenguva dzose uye kutarisa kwepedyo kunokurudzirwa. Titration kumusoro inofanira kuenderera mberi nekuchenjerera.
• Kutanga kwechiito ndeye 10 kusvika 30 maminetsi ekukurumidza-kuburitswa kuumbwa uye inenge 1 awa yekudzora-kuburitswa.
• Nguva yenguva kubva pa3 kusvika kumaawa matanhatu ekukurumidza-kuburitswa kana maawa gumi nemaviri mune inodzorwa-kuburitsa maumbirwo.
• Iyo plasma hafu yeupenyu ndeye maawa matatu kusvika mashanu, uye yakagadzikana mazinga eplasma anowanikwa mukati memaawa makumi maviri nemana kusvika makumi matatu nematanhatu.