PREGABALIN (LYRICA) 300 MG X 56 CAPSULES

Pregabalin adalandira chilolezo kuchokera ku United States Food and Drug Administration (FDA) mu 2004. Amagwiritsidwa ntchito pochiza ululu ndi khunyu. Gulani lyrica pregabalin 300mg pa intaneti ku Australia

Zizindikiro zovomerezeka ndi FDA[1][2][3][4]

• Chithandizo cha ululu wa neuropathic wokhudzana ndi matenda ashuga peripheral neuropathy
• Chithandizo cha ululu wa neuropathic wokhudzana ndi kuvulala kwa msana
• Ululu wa Neuropathic wochokera ku postherpetic neuralgia
• Chithandizo cha Fibromyalgia
• Adjunctive therapy ya kukomoka pang'ono kwa akulu omwe ali ndi khunyu. Gulani lyrica pregabalin 300mg pa intaneti ku Australia

Off-label Ntchito[5][6][7]

• Generalized nkhawa matenda
• Kusokonezeka kwa chikhalidwe cha anthu
• Matenda a bipolar
• kusowa tulo
• Matenda opweteka kwambiri
• Matenda a Pruritus
• Chifuwa chachikulu
• Restless leg syndrome

Pali kusagwirizana kwakukulu pakuchita bwino kwa pregabalin pazovuta zamisala zomwe tazilemba pamwambapa. Chifukwa chake, olembera ayenera kusamala ndikuyang'anira odwala kuti achite bwino pochiza odwala ndi pregabalin. Gulani lyrica pregabalin 300mg pa intaneti ku Australia

Njira yogwira ntchito

Pregabalin ndi yofanana ndi inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Zasinthidwa kukhala analogi ya lipophilic kuti ipititse patsogolo kufalikira kudutsa chotchinga chamagazi ndi ubongo. Komabe, pregabalin samamangiriza mwachindunji ku GABA-A kapena GABA-B receptors. Kuphatikiza apo, sichimapangidwa ndi GABA receptor agonist. M'zitsanzo za nyama, pregabalin imamangiriza ku njira za calcium za presynaptic voltage-gated pa alpha-2-delta subunit mkati mwa minyewa yamanjenje. Kumanga kwa alpha-2-delta subunit kumachepetsa kutulutsa kwa calcium mu neurotransmitter komwe kumachititsa kuti polarization iwonongeke komanso kumachepetsa kutulutsa kwa ma neurotransmitters osangalatsa. Izi zitha kuyambitsa anticonvulsant ndi analgesic zotsatira za pregabalin. Pregabalin alibe zochitika zodziwika pa njira za sodium, dopamine receptors, serotonin Zovomerezeka, opiate receptors ndipo sasintha ntchito ya cyclooxygenase.[8] Gulani lyrica pregabalin 300mg pa intaneti ku Australia

Administration

Pregabalin imaperekedwa pakamwa ndipo imapezeka mu makapisozi kapena mayankho apakamwa. Pambuyo pakamwa, pregabalin imafika pachimake m'magazi a plasma mkati mwa maola 1.5 ndipo imakhazikika mkati mwa maola 24 mpaka 48. Kuyamwa kwa pregabalin sikudalira mlingo. Pregabalin amawoloka mosavuta chotchinga chamagazi ndi ubongo. Anthu sangathe kusokoneza kwambiri pregabalin. Kuchotsa kwake kumakhala ngati mankhwala osasinthika (osakwana 2% opangidwa ndi metabolized) ndi excretion aimpso. Odwala omwe ali ndi vuto laimpso, theka la moyo wapakati ndi maola 6.3. Ofufuza adaphunzira pregabalin pa mlingo mpaka 600 mg patsiku. Komabe, sanapeze 600 mg patsiku kuti apereke phindu lalikulu lowonjezera ndipo sanaloledwe bwino chifukwa cha zotsatira zake. Gulani lyrica pregabalin 300mg pa intaneti ku Australia

Contraindications

• Pregabalin imatsutsana ndi odwala omwe amadziwika kuti ali ndi hypersensitivity kwa pregabalin. Hypersensitivity zimachitikira zachitika odwala kulandira pregabalin, kuphatikizapo angioedema.[19]
• Palibe maphunziro okwanira ndi pregabalin mwa amayi apakati. Pregabalin imatha kuvulaza mwana wosabadwayo. Alangizeni odwala kuti ali ndi chiopsezo kwa mwana wosabadwayo.[20]
• Pregabalin wapezeka mu mkaka wa lactating akazi; motero, kuyamwitsa sikoyenera, ndipo njira ina ndiyo yabwino.[15] Gulani lyrica pregabalin 300mg pa intaneti ku Australia