Njira yogwira ntchito

Oxycodone ndi semisynthetic opioid yokhala ndi wotsutsa katundu pa mu, kappa, ndi delta-mtundu opioid zolandilira, ndi kugwirizana kwambiri kukhala mu-mtundu zolandilira. Mukamangiriza ku ma G-protein ophatikizana awa, oxycodone imapangitsa kusinthana kwa GDP pa gawo la G-alpha la GTP, zomwe zimapangitsa kuti adenylate cyclase atseke komanso kuchepa kwa intracellular cAMP. Kuphulika kwa chizindikirochi kumabweretsa kulepheretsa kwa nociceptive neurotransmitters acetylcholine, dopamine, GABA, noradrenaline, ndi mankhwala P ndi mahomoni glucagon, insulini, somatostatin, ndi vasopressin. Gulani OxyNorm pa intaneti ku Australia - OxyNorm yogulitsa ku Australia

Mofanana ndi ma opioid ena, oxycodone zimayambitsa hyperpolarization ndi kuchepetsa excitability ya neurons mu chapakati mantha dongosolo (CNS). Kuvutika maganizo kwa CNS kumeneku kumabwera chifukwa cha agonistic effect pa kappa-type receptors, zomwe zimapangitsa kutsekedwa kwa njira za calcium zamtundu wa N-voltage-gated, pamene kukondoweza kwa mu ndi delta-type receptors kumatsegula njira za potaziyamu zomwe zimadalira mkati. Gulani OxyNorm pa intaneti ku Australia - OxyNorm yogulitsa ku Australia

Oxycodone ndi zimapukusidwa ndi kwa chiwindi michere CYP3A4 ndi CYP2D6, kubala metabolites noroxycodone ndi oxymorphone, motero. Ma metaboliteswa amachotsedwa m'thupi kudzera mu impso.

Administration

Oxycodone imapezeka kwambiri m'mapiritsi, kapisozi, ndi njira zapakamwa. Pakali pano ikupezeka mu mapiritsi a 10-mg, 20-mg, 40-mg, kapena 80-mg. Opanga anasiya mlingo wa 160-mg mu Meyi 2001 chifukwa cha kuthekera kwakukulu kogwiritsa ntchito molakwika. Oxycodone imapezeka pamodzi ndi mankhwala ena ochepetsa ululu, kuphatikizapo acetaminophen, aspirin, kapena ibuprofen. M'mayiko osankhidwa, oxycodone ikhoza kupezeka m'mitsempha ndi/kapena m'mitsempha. Gulani OxyNorm pa intaneti ku Australia - OxyNorm yogulitsa ku Australia

• Mlingo woyambirira wa oxycodone umakhala mu 5 mpaka 15 mg, maola 4 mpaka 6 aliwonse ngati pakufunika kuti muchepetse ululu wokwanira. Kuchulukitsa kowonjezera kuyenera kukwezera m'mwamba momwe kumafunikira kuti muchepetse ululu, ndikuyang'anira zomwe zingachitike.
• Kwa odwala osatha ululu, tikulimbikitsidwa kuti tititrate mlingo mofanana. Komabe, mankhwalawa amayenera kutengedwa nthawi ndi nthawi kuti ateteze kubwereza kwa ululu kusiyana ndi kuchiza ululu pambuyo poyambira. Gulani OxyNorm pa intaneti ku Australia - OxyNorm yogulitsa ku Australia
• Mapiritsi amapangidwa kuti amwe athunthu ndipo sayenera kuthyoledwa, kutafunidwa, kuphwanyidwa, kapena kusungunuka m'madzi.
• Kuchepetsa mlingo kungakhale kofunikira kwa okalamba ndi odwala omwe ali ndi chiwindi kapena aimpso kulephera. Kuyambitsa mlingo woyambira pa gawo limodzi mwa magawo atatu kapena theka la mlingo wanthawi zonse ndikuyang'anitsitsa mosamala. Kupititsa patsogolo kuyenera kuchitika mosamala kwambiri.
• Kuyambika kwa zochita ndi mphindi 10 mpaka 30 kuti zitheke kumasulidwa ndipo pafupifupi ola limodzi lomasulidwa molamulidwa.
• Kutalika kwa nthawi kumachokera ku maola 3 mpaka 6 kuti atulutsidwe mwamsanga kapena maola 12 m'mapangidwe otulutsidwa.
• Theka la moyo wa plasma ndi maola 3 mpaka 5, ndipo milingo yokhazikika ya plasma imafika mkati mwa maola 24 mpaka 36.