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GULANI OXYCODONE 30MG X 100 TABLETS PA INTANETI | MUSHROOMIFI

Name: OXYCODONE 30MG X 100 TABLETS - Gulani Bowa Wamatsenga Pa intaneti |MushroomiFi
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Oxycodone yakhala ikugwiritsidwa ntchito kuchipatala kuyambira 1917. Gulani Oxycodone Oxycontin 30mg pa intaneti ku Australia
Amaperekedwa kwa anthu kudzera m'mitsempha (iv),
intramuscularly (im),
intranasally (mu),
subcutaneously (sc),
kwenikweni,
matenda,
ndi pakamwa pogwiritsira ntchito njira zotulutsidwa mwamsanga, ndi mapiritsi otulutsidwa mwamsanga ndi olamulidwa. Gulani Oxycodone Oxycontin 30mg pa intaneti ku Australia

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Njira yoyendetsera ma transdermal yayesedwanso mu nyama.

Masiku ano oxycodone amagwiritsidwa ntchito makamaka ngati mapiritsi omasulidwa opweteka kwambiri. Mapiritsi omwe amamasulidwa msangamsanga amagwiritsidwa ntchito popweteka kwambiri kapena kupweteka kwambiri. Parenteral oxycodone ndi njira ina yabwino pamene ma opioid sangathe kuperekedwa pakamwa. Gulani Oxycodone Oxycontin 30mg pa intaneti ku Australia.

Mbiri | Oxycontin for Pain Management | Mushroomif.

Opium ili ndi magulu awiri amankhwala a alkaloids, phenantrenes ndi benzyl-isoquinolines. Imodzi mwa phenantrene alkaloids, thebaine, yomwe ilipo mu 0.2-0.8% ya opium yochokera ku Papaver somniferum ndipo 90% ya zomwe zimatengedwa kuchokera ku morphine wopanda Mtundu wa bracteatum, ndi poizoni kwambiri ndipo alibe mphamvu zochepetsera ululu. Komabe, ndizofunikira kwambiri pazosintha zingapo, kuphatikiza oxycodone.

Oxycodone idachokera ku thebaine mu 1916 ndipo idayambitsidwa muzachipatala ku Germany mu 1917.
Anagwiritsidwa ntchito kumpoto kwa Ulaya makamaka kwa ululu wopweteka kwambiri. Ku Canada, Australia, ndi United States, ankagwiritsidwa ntchito makamaka ngati mankhwala osakaniza ndi acetaminophen, phenacetin, ndi caffeine pa ululu wochepa. Ku Finland, oxycodone yakhala ikugwiritsidwa ntchito ngati opioid yayikulu yoletsa kupweteka kwambiri kuyambira 1960s. Gulani Oxycodone Oxycontin 30mg pa intaneti ku Australia.

Chemistry ndi Basic Pharmacology | OxyContin 30 mg mapiritsi otulutsa nthawi yayitali | Mushroomif.

Molekyu ya oxycodone (6-deoxy-7,8-dehydro-14-hydroxy-3-O-methyl-6-oxomorphine) imakhala ndi mapulaneti awiri (A ndi B) ndi mphete ziwiri za aliphatic (C ndi D). Magulu ofunikira a zochita za analgesic za phenantrenes amalumikizidwa ndi maudindo C3, C6, ndi N.

Oxycodone ili ndi liposolubility yofanana ndi morphine, ndipo onsewo amakhala ochepa kwambiri kusungunuka kwa lipid kuposa fentanyl.

-opioid cholandilira. Gulani Oxycodone Oxycontin 30mg pa intaneti ku Australia

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Kugwirizana kwa μ-opioid receptor kumangiriza kwa oxycodone, komabe, kumakhala kocheperako kuposa kwa morphine kapena methadone.

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Oxymorphone, metabolite yogwira ya oxycodone, imakhala ndi μ-opioid cholandirira chomangirira cholumikizira.

Intramuscular oxymorphone ndi morphine anafaniziridwa ndi odwala omwe ali ndi ululu wosatha chifukwa cha khansa. Intramuscular oxymorphone yatsimikizira kukhala yamphamvu nthawi 8.7 ngati morphine malinga ndi mphamvu ya analgesic yonse komanso nthawi 13 ngati yamphamvu kwambiri potengera mphamvu yayikulu.

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Mu maphunziro a khalidwe la makoswe, oxycodone yafananizidwa ndi Morphine ndipo yawonetsa kufooka kwambiri komanso mwachidule antinociception pakuyezetsa mchira ndi kutentha mbale pambuyo pa intrathecal (it) ndi intracerebroventricular (icv) administration.
Pambuyo pa kayendetsedwe kazinthu (subcutaneous kapena intraperitoneal), oxycodone inasonyezedwa kuti ndi yothandiza kwambiri 2-4 kuposa morphine. Gulani Oxycodone Oxycontin 30mg pa intaneti ku Australia

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Zotsatira izi zawonetsa kuti metabolites yogwira ya oxycodone (mwachitsanzo, oxymorphone) ikhoza kukhala yofunikira mu oxycodone-mediated analgesia. Kafukufuku wogwiritsa ntchito makoswe a Dark Aguti omwe alibe enzyme CYP2D1, yomwe imafunikira O-demethylate oxycodone mu khoswe, komanso otsutsa osiyanasiyana opioid receptor anena kuti antinociceptive Zotsatira za oxycodone zitha kukhala κ-opioid receptor-mediated.

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Zina Zowonjezera

kuchuluka

Mabotolo 1, Mabotolo 2, Mabotolo atatu, Mabotolo 3, Mabotolo 4