PREGABALIN (LYRICA) 300 MG X 56 CAPSULES

Pregabalin nwetara nkwado site na United States Food and Drug Administration (FDA) na 2004. A na-eji ya agwọ mgbu na ọdịdọ. Zụrụ lyrica pregabalin 300mg n'ịntanetị na Australia

Ngosipụta FDA kwadoro[1][2][3][4]

• Ọgwụgwọ nke mgbu neuropathic jikọtara ya na ọrịa mamịrị peripheral neuropathy
• Ọgwụgwọ nke mgbu neuropathic jikọtara ya na ọkpụkpụ azụ azụ
• Ihe mgbu neuropathic sitere na neuralgia postherpetic
• Ọgwụgwọ fibromyalgia
• Ngwọta mgbakwunye maka ọdịdọ mmalite akụkụ-mmalite na ndị okenye nwere Akwụkwụ na-adọ. Zụrụ lyrica pregabalin 300mg n'ịntanetị na Australia

Ejighị akara akara[5][6][7]

• Ọrịa nkwarụ na-akpata
• Ọrịa nchegbu
• imetụ mmadụ n'isi
• ehighị ụra nke ọma
• Ọnọdụ mgbu na-adịghị ala ala
• Pruritus na-adịghị ala ala
• Ụkwara ala ala
• Ụkwụ ụkwụ ụkwụ

Enwere nnukwu esemokwu gbasara ịdị irè nke pregabalin maka ọrịa uche nke edepụtara n'elu. Ya mere, ndị na-ede akwụkwọ kwesịrị ịkpachara anya ma nyochaa ndị ọrịa maka ọganihu ọgwụgwọ mgbe ha na-agwọ ndị ọrịa nwere pregabalin. Zụrụ lyrica pregabalin 300mg n'ịntanetị na Australia

Nhazi nke Action

Pregabalin dị ka ihe mgbochi neurotransmitter gamma-aminobutyric acid (GABA). Emezigharịrị ya ka ọ bụrụ analọgụ lipophilic iji kwalite mgbasa n'ofe mgbochi ụbụrụ ọbara. Agbanyeghị, pregabalin anaghị ejikọta ya na ndị na-anabata GABA-A ma ọ bụ GABA-B. Ọzọkwa, ọ dịghị metabolized na GABA agonist receptor. N'ụdị anụmanụ, pregabalin na-ejikọta ọwa presynaptic voltaji-gated calcium na subunit alpha-2-delta na sistemụ akwara etiti. Njikọ nke subunit alfa-2-delta na-ebelata mbubata calcium na-akpata depolarization n'ime neurons ma belata ntọhapụ nke neurotransmitters na-akpali akpali. Omume a nwere ike ịkọ maka mmetụta anticonvulsant na analgesic nke pregabalin. Pregabalin enweghị ọrụ amara na ọwa sodium, ndị na-anabata dopamine, serotonin anabata, ndị na-anabata opiate na anaghị agbanwe ọrụ cyclooxygenase.[8] Zụrụ lyrica pregabalin 300mg n'ịntanetị na Australia

ochichi

A na-enye Pregabalin ọnụ ma dị na capsules ma ọ bụ ngwọta ọnụ. Na-esochi nchịkwa ọnụ, pregabalin na-erute mkpokọta plasma kacha elu n'ime awa 1.5 wee nweta ọnọdụ kwụ ọtọ n'ime awa 24 ruo 48. Ntinye nke pregabalin na-adabere na dose ahụ. Pregabalin na-agafe ngwa ngwa mgbochi ụbụrụ ọbara. Ụmụ mmadụ enweghị ike metabolize pregabalin nke ukwuu. Mwepụ ya bụ isi dị ka ọgwụ na-agbanweghị agbanwe (ihe na-erughị 2% metabolized) site na mkpochapụ akụrụ. N'ime ndị ọrịa nwere ọrụ gbasara akụrụ nkịtị, ihe nkwụsị ọkara ndụ bụ awa 6.3. Ndị nchọpụta amụwo pregabalin na usoro onunu ogwu ruru 600 mg kwa ụbọchị. Otú ọ dị, ha ahụghị 600 mg kwa ụbọchị iji nye uru ọzọ dị ịrịba ama ma bụrụ nke a na-anabataghị nke ọma n'ihi mmetụta ndị ọzọ. Zụrụ lyrica pregabalin 300mg n'ịntanetị na Australia

Contraindications

• A machibidoro Pregabalin n'ime ndị ọrịa nwere hypersensitivity na pregabalin. Mmeghachi omume hypersensitivity mere na ndị ọrịa na-anata pregabalin, gụnyere angioedema.[19]
• Enweghị ọmụmụ ihe zuru oke na pregabalin na ụmụ nwanyị dị ime. Pregabalin nwere ike imerụ nwa ebu n'afọ. Nye ndị ọrịa ndụmọdụ na enwere ike ime nwa ebu n'afọ.[20]
• Achọpụtala Pregabalin n'ime mmiri ara nke ụmụ nwanyị na-enye nwa ara; ya mere, inye nwa ara adịghị mma, a na-ahọrọkwa onye nnọchi anya ọzọ.[15] Zụrụ lyrica pregabalin 300mg n'ịntanetị na Australia