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Oxycodone bụ opioid semisynthetic nwere ya eme ihe ike Njirimara na mu, kappa, na ụdị delta-ụdị opioid anabata, nke kachasi ike bụ maka ụdị mu-ụdị nnabata. Mgbe ejikọtara ya na ndị nnabata G-protein jikọtara ọnụ, oxycodone na-akpali mgbanwe nke GDP na mpaghara G-alpha maka GTP, na-ebute mgbochi nke adenylate cyclase na mbelata na cAMP intracellular. Mgbama mgbama a na-eduga na mgbochi nke nociceptive neurotransmitters acetylcholine, dopamine, GABA, noradrenaline, na ihe P na homonụ glucagon, insulin, somatostatin, na vasopressin. Zụrụ OxyNorm n'ịntanetị na Australia - OxyNorm maka ọrịre Australia

Dị ka ọ dị na opioids ndị ọzọ, oxycodone na-akpata hyperpolarization na mbelata excitability nke neurons na Central ụjọ usoro (CNS). Nke a na-akpata ịda mbà n'obi CNS n'ozuzu ya site na mmetụta agonistic na ụdị kappa, nke na-eduga na mmechi nke ọwa calcium voltaji-gated N-ụdị, ebe mkpali nke mu na ụdị ndị na-anabata delta na-emepe ọwa potassium na-emezi calcium na-adabere n'ime. Zụrụ OxyNorm n'ịntanetị na Australia - OxyNorm maka ọrịre Australia

Oxycodone bụ metabolized site na imeju enzymes CYP3A4 na CYP2D6, na-emepụta metabolites noroxycodone na oxymorphone, n'otu n'otu. Metabolites ndị a na-esi na akụrụ na-apụ apụ n'ahụ.

ochichi

Oxycodone dị n'ọtụtụ ebe na mbadamba mbadamba, capsule, na ngwọta ọnụ. Ọ dị ugbu a na 10-mg, 20-mg, 40-mg, ma ọ bụ 80-mg pill. Ndị nrụpụta kwụsịrị ọgwụ 160-mg na Mee 2001 n'ihi nnukwu ike iji ya eme ihe. Oxycodone dị na ngwakọta yana ọgwụ analgesics ndị ọzọ, gụnyere acetaminophen, aspirin, ma ọ bụ ibuprofen. Na mba ahọpụtara, oxycodone nwekwara ike ịdị n'ụdị intramuscular na/ma ọ bụ eriri afọ. Zụrụ OxyNorm n'ịntanetị na Australia - OxyNorm maka ọrịre Australia

• Usoro izizi nke oxycodone akwadoro dị na 5 ruo 15 mg, kwa awa anọ ruo isii ka ọ dị mkpa maka analgesia zuru oke nke nnukwu mgbu. Ntugharị ọzọ kwesịrị ịgbatị elu dị ka achọrọ maka nchịkwa mgbu, na nlebara anya na nlekota maka mmetụta ndị nwere ike ime.
• Maka ndị ọrịa na ala ala mgbu, a na-atụ aro ka titrate onunu ogwu n'otu ụzọ ahụ. Otú ọ dị, a ghaghị ịṅụ ọgwụ ahụ n'oge a na-ahazi mgbe nile iji gbochie nlọghachi nke mgbu na-emegide ịgwọ mgbu mgbe ọ malitesịrị. Zụrụ OxyNorm n'ịntanetị na Australia - OxyNorm maka ọrịre Australia
• Mbadamba ụrọ ka e bu n'obi were ha niile, a gaghị agbajikwa, tachaa, gwepịa ya ma ọ bụ gbazee n'ime mmiri mmiri.
• Mbelata dose nwere ike ịdị mkpa maka ndị agadi na ndị ọrịa nwere ịba ọcha n'anya ma ọ bụ gbasara akụrụ. A na-atụ aro ịmalite usoro mmalite na otu ụzọ n'ụzọ atọ ruo otu ọkara usoro ọgwụgwọ a na-emebu yana nleba anya. Titration n'elu kwesịrị ịga n'ihu n'ọ̀tụ̀tụ̀ nlezianya anya.
• Mmalite nke omume bụ nkeji 10 ruo 30 maka nhazi mwepụta ozugbo yana ihe dịka elekere 1 maka ntọhapụ a na-achịkwa.
• Ogologo oge dị site na awa 3 ruo 6 maka mwepụta ozugbo ma ọ bụ awa iri na abụọ n'usoro ntọhapụ ejiri chịkwaa.
• Ọkara ndụ plasma bụ awa 3 ruo 5, a na-erukwa ọkwa plasma kwụsiri ike n'ime awa 24 ruo 36.