Ka hana hana

ʻO ka Oxycodone kahi opioid semisynthetic me agonistic mau waiwai ma ka mu, kappa, a me ka delta-type opioid receptors, me ka pili ikaika loa no ka mu-type receptors. Ma ka hoʻopaʻa ʻana i kēia mau mea hoʻokipa G-protein, hoʻoulu ka oxycodone i ka hoʻololi ʻana o GDP ma ka subunit G-alpha no GTP, ka hopena i ka pale ʻana o ka adenylate cyclase a me ka emi ʻana o ka cAMP intracellular. Ke alakaʻi nei kēia hōʻailona hōʻailona i ka hopena o ka nociceptive neurotransmitters acetylcholine, dopamine, GABA, noradrenaline, a me ka waiwai P a me nā hormones glucagon, insulin, somatostatin, a me vasopressin. E kūʻai aku iā OxyNorm ma ka pūnaewele ma Australia - OxyNorm no ke kūʻai aku iā Australia

E like me nā opioids ʻē aʻe, oxycodone ke kumu o ka hyperpolarization a me ka ho'ēmiʻana i ka excitability o nā neurons i loko o ke kikowaena pūnaewele (CNS). ʻO kēia puʻuwai CNS maʻamau ka hopena ma muli o ka hopena agonistic ma nā ʻano kappa-type receptors, kahi e alakaʻi ai i ka pani ʻana o nā kahawai calcium-gated ʻano N-type, ʻoiai ka hoʻoulu ʻana o ka mu a me ka delta-type receptors e wehe i ka calcium-hilinaʻi i loko-hoʻoponopono ʻana i nā kahawai potassium. E kūʻai aku iā OxyNorm ma ka pūnaewele ma Australia - OxyNorm no ke kūʻai aku iā Australia

Hoʻopili ʻia ka Oxycodone e nā enzyme hepatic CYP3A4 a me CYP2D6, e hana ana i nā metabolites noroxycodone a me oxymorphone, kēlā me kēia. Hoʻokuʻu ʻia kēia mau metabolites mai ke kino ma o nā puʻupaʻa.

hooponopono

Oxycodone Loaʻa nui ʻia ma ka papa, ka capsule, a me nā hoʻonā waha. Loaʻa iā ia i kēia manawa ma 10-mg, 20-mg, 40-mg, a i ʻole 80-mg pills. Ua hoʻopau nā mea hana i ka 160-mg i ka Mei 2001 ma muli o ka hiki ke hoʻohana hewa. Loaʻa ka Oxycodone i hui pū me nā analgesics ʻē aʻe, me ka acetaminophen, aspirin, a i ʻole ibuprofen. Ma nā ʻāina i koho ʻia, hiki ke loaʻa ka oxycodone ma nā ʻano intramuscular a / a i ʻole intravenous pū kekahi. E kūʻai aku iā OxyNorm ma ka pūnaewele ma Australia - OxyNorm no ke kūʻai aku iā Australia

• ʻO nā kumu mua i manaʻo ʻia o ka oxycodone aia ma ka laulā 5 a 15 mg, kēlā me kēia 4 a 6 mau hola e like me ka mea e pono ai no ka analgesia kūpono o ka ʻeha nui. Pono e hoʻonui i ka dosing i luna e like me ka mea e pono ai no ka mālama ʻana i ka ʻeha, me ka nānā ʻana a me ka nānā ʻana no nā hopena ʻaoʻao.
• No nā maʻi me maʻi ʻeha, ua ʻōlelo ʻia e titrate dosage ma ke ʻano like. Eia nō naʻe, pono e lawe ʻia ka lāʻau lapaʻau i nā manawa i hoʻonohonoho mau ʻia e pale i ka hoʻi hou ʻana o ka ʻeha ma mua o ka mālama ʻana i ka ʻeha ma hope o ka hoʻomaka ʻana. E kūʻai aku iā OxyNorm ma ka pūnaewele ma Australia - OxyNorm no ke kūʻai aku iā Australia
• Manaʻo ʻia nā papa e lawe holoʻokoʻa a ʻaʻole pono e haki, ʻoluʻolu, ʻokiʻoki a hoʻoheheʻe ʻia i loko o ka wai.
• Pono paha ka hoʻemi ʻana i ka nui no ka poʻe ʻelemakule a me nā poʻe maʻi me ka hepatic a i ʻole renal. Hoʻomaka ka hoʻomaka ʻana ma kahi hapakolu a i ka hapalua o nā kau maʻamau a me ka nānā pono ʻana. Pono e hoʻomau ka titration i luna me ka akahele.
• ʻO ka hoʻomaka ʻana o ka hana he 10 a 30 mau minuke no ka hoʻopuka hoʻokuʻu koke ʻana a ma kahi o 1 hola no ka hoʻokuʻu ʻana.
• ʻO ka lōʻihi o ka lōʻihi mai 3 a 6 mau hola no ka hoʻokuʻu koke ʻana a i ʻole 12 mau hola i nā hoʻopuka hoʻokuʻu ʻia.
• ʻO ka hapalua o ke ola o ka plasma he 3 a 5 mau hola, a hiki i nā pae plasma kūpaʻa i loko o 24 a 36 mau hola.