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Oxycodone haesale e le ts'ebeliso ea bongaka ho tloha 1917. Reka Oxycodone Oxycontin 30mg inthaneteng Australia
E 'nile ea fuoa batho ka methapo (iv),
ka intramuscularly (im),
intranasally (ka),
subcutaneously (sc),
hantle,
lefu la sethoathoa,
le ka molomo ho sebelisa litharollo tsa hang-hang, le matlapa a ho lokolloa hang-hang le a laoloang. Reka Oxycodone Oxycontin 30mg inthaneteng Australia

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Tsela ea tsamaiso ea transdermal e boetse e lekoa liphoofolong.

Kajeno oxycodone e sebelisoa haholo-holo e le matlapa a laoloang bakeng sa bohloko bo sa foleng. Tharollo ea hang-hang le matlapa a sebelisoa bakeng sa bohloko bo matla kapa bakeng sa bohloko bo matla. Parenteral oxycodone ke khetho e ntle ha li-opioid li sa khone ho tsamaisoa ka molomo. Reka Oxycodone Oxycontin 30mg inthaneteng Australia.

Nalane | Oxycontin bakeng sa Taolo ea Bohloko | Li-mushroom.

Opium e na le lihlopha tse peli tsa lik'hemik'hale tsa alkaloids, phenantrenes le benzyl-isoquinolines. E 'ngoe ea li-alkaloids tsa phenantrene, thebaine, e teng ka 0.2-0.8% ea opium e nkiloeng ho Papaver somniferum 'me ho 90% ea e ntšitsoeng ho morphine-free Papaver bracteatum, e chefo e feteletseng 'me ha e na lisebelisoa tsa analgesic. Leha ho le joalo, ke selelekela sa bohlokoa sa lihlahisoa tse 'maloa tsa phetoho, ho kenyeletsoa oxycodone.

Oxycodone e nkiloe ho thebaine ka 1916 mme e ile ea kenngoa ts'ebetsong ea bongaka Jeremane ka 1917.
E ne e sebelisoa karolong e ka leboea ea Europe haholo-holo bakeng sa bohloko bo bohloko. Canada, Australia le United States, e ne e sebelisoa haholo-holo e le moriana o kopantsoeng le acetaminophen, phenacetin le caffeine bakeng sa bohloko bo itekanetseng. Finland, oxycodone esale e sebelisoa e le opioid ea mantlha ea botsoali bakeng sa mahlaba a bohloko ho tloha ka bo-1960. Reka Oxycodone Oxycontin 30mg inthaneteng Australia.

Chemistry le Basic Pharmacology | OxyContin 30 mg matlapa a ho lokolloa ha nako e telele | Li-mushroom.

Molek'hule ea oxycodone (6-deoxy-7,8-dehydro-14-hydroxy-3-O-methyl-6-oxomorphine) e na le mehele e 'meli ea planar (A le B) le mehele e' meli ea aliphatic (C le D). Lihlopha tsa bohlokoa bakeng sa liketso tsa analgesic tsa phenantrenes li amahanngoa le maemo a C3, C6, le N.

Oxycodone e na le liposolubility e ts'oanang le morphine, 'me ka bobeli ha li na lipid tse qhibilihang ho feta fentanyl.

- receptor ea opioid. Reka Oxycodone Oxycontin 30mg inthaneteng Australia

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Kamano e tlamang ea μ-opioid receptor ea oxycodone, leha ho le joalo, e ka tlase ho ea morphine kapa methadone.

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Oxymorphone, metabolite e sebetsang ea oxycodone, e na le kamano e tlamang ea μ-opioid e phahameng haholo.

Intramuscular oxymorphone le morphine li ile tsa bapisoa ho bakuli ba nang le bohloko bo sa foleng ka lebaka la mofetše. Intramuscular oxymorphone e ipakile e le makhetlo a 8.7 e le matla joalo ka morphine ho latela phello ea analgesic e felletseng le makhetlo a 13 e le matla ho latela phello e phahameng.

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Lithutong tsa boitšoaro ho likhoto, oxycodone e bapisitsoe le Morphine 'me e bontšitse antinociception e fokolang haholo le e khuts'oane ka mohatla le liteko tsa hot plate ka mor'a tsamaiso ea intrathecal (it) le intracerebroventricular (icv).
Ka mor'a tsamaiso ea tsamaiso (subcutaneous kapa intraperitoneal), oxycodone e bontšitsoe hore e sebetsa ka makhetlo a 2-4 ho feta morphine. Reka Oxycodone Oxycontin 30mg inthaneteng Australia

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Liphetho tsena li bonts'itse hore metabolite e sebetsang ea oxycodone (mohlala, oxymorphone) e ka ba ea bohlokoa ho analgesia ea oxycodone-mediated. Lithuto tse sebelisang likhoto tsa Dark Aguti tse haelloang ke enzyme CYP2D1, e hlokehang ho O-demethylate oxycodone ho rat, le bahanyetsi ba fapaneng ba opioid receptor ba khothalelitse hore antinociceptive litlamorao tsa oxycodone e ka ba κ-opioid receptor-mediated.

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Tlhahisoleseling e 'Ngoe

bongata

1, libotlolo tse 2, libotlolo tse 3, tse 4, tse 5.