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Tiirkan socda waxa uu u heellan yahay isku xidhka caafimaad ee adag ee u dhexeeya cilmu-nafsiga iyo daryeelka aasaasiga ah—laba goobood oo si aan kala go' lahayn ugu xidhan. Ka iibso Tramadol 200mg online gudaha Australia

Tramadol (Ultram^®) waa xanuun-joojin caadi ahaan loo qoro sababta oo ah khatarteeda balwadda oo yara hoosaysa iyo nabdoonaanta ka wanaagsan marka la barbar dhigo opiates kale. Si kastaba ha ahaatee, laba falcelin oo xun ayaa la og yahay inay suurtogal tahay inay ku dhacaan tramadol- suuxdin iyo serotonin syndrome. Labadan falcelin xun ayaa laga yaabaa inay soo baxaan inta lagu jiro daweynta tramadol monotherapy, laakiin waxay u muuqdaan inay aad ugu dhowdahay inay soo baxaan inta lagu jiro si xun u isticmaalka / xad-dhaafka ah iyo sidoo kale isku-dhafka daawooyinka kale, gaar ahaan daawooyinka niyadjabka. Maqaalkan, waxaan dib u eegeynaa xogta la xiriirta tramadol, suuxdin, iyo xanuunka serotonin. Isgoysyada dawooyinka ayaa si cad u khuseeya dhakhaatiirta dhimirka iyo takhaatiirta daryeelka aasaasiga ah labadaba. Ka iibso Tramadol 200mg online gudaha Australia

Keywords: tramadol, xanuunka xanuunka, opiate, suuxdin, serotonin syndrome, antidepressant, polypharmacy, dhakhtarka maskaxda-dhakhtarka interneedka

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Hordhac

Sida laga soo xigtay Miller et al.¹ Xanuunka dabadheeraadku wuxuu saameeyaa tiro badan oo bukaanno Maraykan ah wuxuuna keenaa balaayiin doolar oo kharashyada daryeelka caafimaadka sannadlaha ah. Australia gudaheeda, kharashka maaraynta xanuunka daba-dheeraada waxaa lagu qiyaasaa inuu yahay $34 bilyan sanadkii.² Marka la eego beddelka maandooriyaha ee daaweynta, tramadol (Ultram^®) waa xabbad farmaajo gaar ah oo la dagaallanka xanuunka joogtada ah. Si loo caddeeyo caannimadeeda, dawooyinka tramadol ee Kanada waxay gaadheen ku dhawaad 26 milyan sannadkii 2006, taasoo ka dhigan wadarta iibka $800 milyan.³ Daabacaaddan Interface-ka, waxaanu kaga hadlaynaa laba dhacdo oo khatar ah oo iman kara oo la xidhiidha xanuunka-xanuuninta sida caadiga ah loo qoro - suuxdin iyo xanuunka serotonin. Ka iibso Tramadol 200mg online gudaha Australia

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Sharaxaada Tramadol

Tramadol waa dawo xanuunka kadeedka ah oo ah analoogga synthetic ee codeine. Marka la barbar dhigo opiates kale, tramadol waxa ay caan ku tahay in ay yaraato awoodda xad-gudubka iyo neefsiga oo yaraada niyad-jabka.⁴ Marka la eego saamaynta neurotransmitter gaar ah, heerka dhexe, tramadol waa agonist mu-opioid receptor. Xidhiidhka tramadol ee mu-opioid reseptors (saamaynta xanuunka) ayaa 10-laab ka yar koodka. Si kastaba ha noqotee, dheef-shiid kiimikaadka firfircoon ee tramadol, o-desmethyltramadol, wuxuu leeyahay xiriir aad uga weyn (ilaa 200-laab) marka loo eego xarunta waalidka. Marka lagu daro saameynteeda dhexe ee mu receptors, heerka durugsan, tramadol waxay joojisaa serotonin iyo norepinephrine dib u qaadashada. Saamayntan dambe waxay u badan tahay inay noqdaan shay muhiim u ah xanuunka xanuunka, laakiin waxa kale oo laga yaabaa inay ku xisaabtamaan qaar ka mid ah sifooyinka xun ee daawada. Ka iibso Tramadol 200mg online gudaha Australia

Sida laga soo xigtay Reeves iyo Cox,⁵ tramadol waxay leedahay sifooyin badan oo la mid ah venlafaxine, oo ay ku jiraan isku ekaanshaha qaabdhismeedka iyo xannibaadda dib u soo celinta serotonergic/noradrenergic. Iyadoo la ilaalinayo aragtidan, Yalcin et al⁶ ku sifee tramadol inay leedahay saameyn liddi ku ah niyad-jabka. La yaab ma leh, iyadoo la isticmaalayo chromatography dareere ah si loo ogaado heerarka tramadol ee kaadida, venlafaxine waxay keeni kartaa natiijooyin been abuur ah.⁷

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Isdhexgalka daroogada

Tramadol wuxuu xisaabiyaa tiro badan oo isdhexgalka daroogada ah. Tusaale ahaan, daraasad Australian veterans ah, Roughead et al⁸ 46,859 ka qaybgalayaasha oo qaatay dawooyinka lidka diiqadda ayaa baadhay isdhexgalka daroogada xun. Boqolkiiba 8.1 ee la kulmay is dhexgalkaan, tramadol waxay ahayd daawada ugu badan ee la soo daristay (3.6%). Ka iibso Tramadol 200mg online gudaha Australia

Isdhexgalkaas kala duwan, tramadol waxa ay awood u leedahay in ay kiciso laba dhacdo oo cajiib ah - suuxdin iyo serotonin syndrome. Kuwaas waxaa laga yaabaa inay soo baxaan inta lagu jiro daweynta tramadol monotherapy ha ahaato mid joogto ah ama qiyaaso xad-dhaaf ah, laakiin waxay u badan tahay inta lagu guda jiro isku-dhafka tramadol ee daawooyinka niyadjabka (Shaxda). (Shaxda11 iyo iyo 22).^4,9 (Ka sokow dawooyinka niyad-jabka, tramadol waxa laga yaabaa inay la falgasho tiro dawooyin kale oo nafsi ah oo ay ku jiraan antipsychotics iyo anticonvulsanants.) Ka iibso Tramadol 200mg online gudaha Australia