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1. NAME OF MEDICINE

Panadeine® Tablets / Caplets. Buy Panadeine Prodeine Forte online in Australia

2. QUALITATIVE AND QUANTITATIVE COMPOSITION

Paracetamol 500mg, Codeine Phosphate 8mg

3. PHARMACEUTICAL FORM

Active ingredients Chemical structure CAS Registry
Number
Paracetamol 103-90-2
Codeine Phosphate 41444-62-6
Tablets: Flat, round white 1.27cm tablet with bevelled edges. Front face marking
“PANADEINE” with a break bar on the back face
Caplets: white, uncoated capsule-shaped tablets, marked Panadeine with break-bar
on the back face. Buy Panadeine Prodeine Forte online in Australia

4. CLINICAL PARTICULARS

4.1 Therapeutic Indications

For the temporary relief of pain and discomfort associated with
• Headache • Arthritis
• Migraine headache • Toothache
• Tension headache • Neuralgia
• Period pain • Cold & flu symptoms
• Back pain • Dental procedures
• Muscle pain • Sore throat
Reduces fever. Buy Panadeine Prodeine Forte online in Australia

4.2 Dosage and Administration

18 years – Adults:
2 tablets/caplets – to be taken with water four to six hours if necessary. Maximum 8
tablets/caplets in 24 hours. Do not use in children aged below 18 years.
Do not exceed the stated dose or take for more than three days without a doctors
advice.
If symptoms persist or worsen medical advice must be sought.
Should not be used with other paracetamol or codeine-containing products.
Must not be used in children under 18 years. Buy Panadeine Prodeine Forte online in Australia

4.3 Contraindications

• Previous history of hypersensitivity to paracetamol, codeine, opioid
analgesics, or excipients.
• Active alcoholism
• Acute respiratory depression
• In mothers who are breastfeeding.
• Under the age of 18 years.
• Those who are known to be CYP2D6 ultra-rapid metabolisers. If the
patient is an extensive or ultra-rapid CYP2D6 metaboliser there is an
increased risk of developing symptoms of opioid toxicity, even at
commonly prescribed doses. General symptoms of opioid toxicity include
confusion, somnolence, shallow breathing, small pupils, nausea, vomiting,
constipation and lack of appetite. In severe cases this may include
symptoms of circulatory and respiratory depression which may be life
threatening and very rarely fatal. Buy Panadeine Prodeine Forte online in Australia

4.4 Special Warnings and Precautions for Use

Adults: Not to be taken for more than three days unless on the advice of a doctor.
Panadeine should be administered with caution to patients with hepatic or renal
dysfunction.
Patients with obstructive bowel disorders or acute abdominal conditions should
consult a doctor before using this product.
Patients with a history of cholecystectomy should consult a doctor before using this
product as it may cause acute pancreatitis in some patients.
In patients with glutathione depleted states such as sepsis, the use of paracetamol
may increase the risk of metabolic acidosis.
Codeine should be used with caution in patients with CNS depression or decreased
respiratory reserve. Buy Panadeine Prodeine Forte online in Australia