PREGABALIN (LYRICA) 300 MG X 56 CAPSULES

Pregabalin tau txais kev pom zoo los ntawm United States Food and Drug Administration (FDA) hauv xyoo 2004. Nws yog siv los kho qhov mob thiab qaug dab peg. Yuav lyrica pregabalin 300mg online hauv Australia

FDA pom zoo Indications[1][2][3][4]

• Kev kho mob ntawm neuropathic mob txuam nrog mob ntshav qab zib peripheral neuropathy
• Kev kho mob neuropathic cuam tshuam nrog kev raug mob ntawm tus txha caj qaum
• Neuropathic mob los ntawm postherpetic neuralgia
• Kev kho mob ntawm fibromyalgia
• Adjunctive therapy rau kev qaug dab peg ib nrab ntawm cov neeg laus uas muaj mob vwm. Yuav lyrica pregabalin 300mg online hauv Australia

Kev siv daim ntawv lo[5][6][7]

• Generalized kev txhawj xeeb tsis meej
• Kev txhawj xeeb tsis xws luag
• bipolar disorder
• insomnia
• Mob mob
• Chronic Pruritus
• Mob khaub thuas hnoos
• Restless Leg Syndrome

Muaj kev tsis pom zoo tseem ceeb txog kev ua haujlwm ntawm pregabalin rau cov kev puas siab puas ntsws uas tau teev tseg saum toj no. Yog li, cov kws kho mob yuav tsum tau ceev faj thiab saib xyuas cov neeg mob kom kho tau zoo thaum kho cov neeg mob nrog pregabalin. Yuav lyrica pregabalin 300mg online hauv Australia

Mechanism of Action

Pregabalin yog structurally zoo ib yam li inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Nws tau raug hloov kho los ua ib qho lipophilic analog los txhim kho kev sib kis thoob plaws cov ntshav-hlwb teeb meem. Txawm li cas los xij, pregabalin tsis ncaj qha khi rau GABA-A lossis GABA-B receptors. Tsis tas li ntawd, nws tsis yog metabolized rau GABA receptor agonist. Hauv cov qauv tsiaj, pregabalin khi rau presynaptic voltage-gated calcium channels ntawm alpha-2-delta subunit hauv nruab nrab paj hlwb cov ntaub so ntswg. Kev khi ntawm alpha-2-delta subunit txo qis depolarization-induced influx ntawm calcium rau hauv neurons thiab txo qhov tso tawm ntawm excitatory neurotransmitters. Qhov kev txiav txim no tuaj yeem suav rau cov tshuaj tiv thaiv kab mob thiab tshuaj tua kab mob ntawm pregabalin. Pregabalin tsis paub ua haujlwm ntawm sodium channels, dopamine receptors, serotonin receptors, opiate receptors thiab tsis hloov kev ua haujlwm cyclooxygenase.[8] Yuav lyrica pregabalin 300mg online hauv Australia

Administration

Pregabalin yog siv los ntawm qhov ncauj thiab muaj nyob rau hauv cov tshuaj ntsiav lossis cov tshuaj hauv qhov ncauj. Tom qab kev tswj hwm qhov ncauj, pregabalin nce mus txog qhov siab tshaj plaws ntawm cov ntshav ntshav hauv 1.5 teev thiab ua tiav lub xeev tsis tu ncua hauv 24 txog 48 teev. Kev nqus ntawm pregabalin yog ywj siab ntawm koob tshuaj. Pregabalin nkag mus hla cov ntshav-hlwb barrier. Tib neeg tsis tuaj yeem metabolize pregabalin ntau heev. Nws tshem tawm feem ntau yog cov tshuaj tsis hloov pauv (tsawg dua 2% metabolized) los ntawm lub raum tso tawm. Hauv cov neeg mob uas lub raum ua haujlwm tsis zoo, qhov kev tshem tawm ib nrab ntawm lub neej yog 6.3 teev. Cov kws tshawb fawb tau kawm pregabalin ntawm qhov ntau npaum li 600 mg ib hnub twg. Txawm li cas los xij, lawv tsis pom 600 mg ib hnub twg los muab cov txiaj ntsig tseem ceeb ntxiv thiab tsis tau txais txiaj ntsig zoo vim muaj kev phiv. Yuav lyrica pregabalin 300mg online hauv Australia

Contraindications

• Pregabalin yog contraindicated nyob rau hauv cov neeg mob uas muaj ib tug paub hypersensitivity rau pregabalin. Cov tshuaj tiv thaiv hypersensitivity tau tshwm sim hauv cov neeg mob tau txais pregabalin, suav nrog angioedema.[19]
• Tsis muaj kev tshawb fawb txaus nrog pregabalin hauv cov poj niam cev xeeb tub. Pregabalin tuaj yeem ua rau muaj kev phom sij rau menyuam hauv plab. Qhia rau cov neeg mob tias muaj kev pheej hmoo rau tus menyuam hauv plab.[20]
• Pregabalin tau kuaj pom hauv cov mis nyuj ntawm cov poj niam lactating; Yog li, kev pub niam mis tsis yog qhov xav tau, thiab xav tau lwm tus neeg sawv cev.[15] Yuav lyrica pregabalin 300mg online hauv Australia