Mechanism of Action

Oxycodone yog semisynthetic opioid nrog agonistic Cov khoom ntawm mu, kappa, thiab delta-type opioid receptors, nrog rau kev sib raug zoo tshaj plaws rau mu-type receptors. Raws li kev khi rau cov G-protein coupled receptors, oxycodone txhawb kev sib pauv ntawm GDP ntawm G-alpha subunit rau GTP, ua rau inhibition ntawm adenylate cyclase thiab txo qis hauv intracellular cAMP. Qhov teeb meem no ua rau muaj qhov cuam tshuam rau qhov cuam tshuam ntawm nociceptive neurotransmitters acetylcholine, dopamine, GABA, noradrenaline, thiab tshuaj P thiab cov tshuaj hormones glucagon, insulin, somatostatin, thiab vasopressin. Yuav OxyNorm online hauv Australia - OxyNorm muag Australia

Raws li nrog rau lwm cov tshuaj opioids, cov tsoos tsho ua rau hyperpolarization thiab txo excitability ntawm neurons nyob rau hauv lub hauv paus paj hlwb (CNS). Qhov kev nyuaj siab CNS no tshwm sim los ntawm kev cuam tshuam ntawm kappa-type receptors, uas ua rau kaw N-type voltage-gated calcium channels, thaum stimulation ntawm mu thiab delta-type receptors qhib calcium-dependent inward-rectifying potassium channels. Yuav OxyNorm online hauv Australia - OxyNorm muag Australia

Oxycodone yog metabolized los ntawm hepatic enzymes CYP3A4 thiab CYP2D6, tsim cov metabolites noroxycodone thiab oxymorphone, feem. Cov metabolites no tau tawm ntawm lub cev los ntawm lub raum.

Administration

oxycodone yog dav muaj nyob rau hauv ntsiav tshuaj, tshuaj ntsiav, thiab qhov ncauj daws. Tam sim no muaj nyob rau hauv 10-mg, 20-mg, 40-mg, lossis 80-mg ntsiav tshuaj. Cov neeg tsim khoom tau txiav tawm 160-mg koob tshuaj nyob rau lub Tsib Hlis 2001 vim tias muaj peev xwm siv tsis raug ntau. Oxycodone muaj nyob rau hauv ua ke nrog lwm yam tshuaj, xws li acetaminophen, aspirin, los yog ibuprofen. Hauv qee lub tebchaws, oxycodone tuaj yeem muaj nyob rau hauv cov ntaub ntawv intramuscular thiab / lossis cov ntawv tso rau hauv cov hlab ntsha thiab. Yuav OxyNorm online hauv Australia - OxyNorm muag Australia

• Thawj koob tshuaj pom zoo ntawm oxycodone yog nyob rau hauv qhov ntau ntawm 5 txog 15 mg, txhua 4 mus rau 6 teev raws li xav tau rau qhov txaus ntshai ntawm qhov mob hnyav. Kev noj tshuaj ntxiv yuav tsum titrate nce siab raws li qhov xav tau rau kev tswj qhov mob, nrog rau kev saib xyuas thiab saib xyuas cov kev mob tshwm sim.
• Rau cov neeg mob mob mob ntev mob, nws raug nquahu kom titrate ntau npaum li qub. Txawm li cas los xij, cov tshuaj yuav tsum tau noj nyob rau lub sijhawm teem tseg kom tsis txhob rov tshwm sim ntawm qhov mob uas tsis yog kho qhov mob tom qab nws pib. Yuav OxyNorm online hauv Australia - OxyNorm muag Australia
• Cov ntsiav tshuaj yog npaj kom muab tag nrho thiab yuav tsum tsis txhob tawg, zom, crushed, los yog yaj hauv kua.
• Kev txo koob tshuaj yuav tsim nyog rau cov neeg laus thiab cov neeg mob uas muaj kab mob siab lossis lub raum tsis ua haujlwm. Pib pib koob tshuaj pib ntawm ib feem peb mus rau ib nrab ntawm cov koob tshuaj ib txwm thiab kev saib xyuas ze yog pom zoo. Titration upwards yuav tsum ua raws li ceev faj.
• Qhov pib ntawm kev nqis tes ua yog 10 mus rau 30 feeb rau kev tso tawm tam sim thiab li 1 teev rau kev tswj-tso tawm.
• Lub sijhawm ntev yog los ntawm 3 mus rau 6 teev rau kev tso tawm tam sim lossis 12 teev hauv kev tswj hwm-tso cov qauv.
• Lub plasma ib nrab-lub neej yog 3 mus rau 5 teev, thiab cov qib plasma ruaj khov tau mus txog hauv 24 mus rau 36 teev.