-ʻo ia ka mea lawe opioid. E kūʻai i ka Oxycodone Oxycontin 30mg ma ka pūnaewele ma Australia

ʻO ka μ-opioid receptor binding affinity o ka oxycodone, ʻoi aku ka liʻiliʻi ma mua o ka morphine a me ka methadone.

ʻO ka Oxymorphone, ka metabolite ikaika o ka oxycodone, he kiʻekiʻe kiʻekiʻe ka μ-opioid receptor binding affinity.

Hoʻohālikelike ʻia ka oxymorphone intramuscular a me ka morphine i nā poʻe maʻi me ka ʻeha mau ma muli o ke kanesa. ʻO ka oxymorphone Intramuscular i hōʻike ʻia he 8.7 mau manawa e like me ka morphine ma ke ʻano o ka hopena analgesic a me 13 mau manawa e like me ka mana o ka hopena kiʻekiʻe.

Ma nā haʻawina pili i nā ʻiole, oxycodone ua hoohalikeia me Morphine a ua hōʻike ʻoi aku ka nāwaliwali a me ka pōkole o ka antinociception ma ka huelo flick a me nā hoʻāʻo pā wela ma hope o ka intrathecal (it) a me ka intracerebroventricular (icv).
Ma hope o ka hoʻoponopono pūnaewele (subcutaneous a i ʻole intraperitoneal), ua hōʻike ʻia ka oxycodone he 2-4 mau manawa ʻoi aku ka maikaʻi ma mua o ka morphine. E kūʻai i ka Oxycodone Oxycontin 30mg ma ka pūnaewele ma Australia

Ua hōʻike ʻia kēia mau hopena he mea nui paha nā metabolites ikaika o ka oxycodone (e laʻa, oxymorphone) i ka analgesia-mediated oxycodone. ʻO nā haʻawina e hoʻohana ana i nā ʻiole Dark Aguti i nele i ka enzyme CYP2D1, i koi ʻia e O-demethylate oxycodone i loko o ka ʻiole, a ua ʻōlelo ʻia nā ʻano antagonists o ka opioid receptor i ka antinociceptive Hiki i nā hopena o ka oxycodone ke κ-opioid receptor-mediated.